Gene
carmil3
- ID
- ZDB-GENE-070912-183
- Name
- capping protein regulator and myosin 1 linker 3
- Symbol
- carmil3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Acts upstream of or within Kupffer's vesicle development; cell migration; and determination of heart left/right asymmetry. Predicted to be located in cytoplasm. Predicted to be active in lamellipodium and plasma membrane. Is expressed in brain; eye; gut; heart; and spinal cord. Orthologous to human CARMIL3 (capping protein regulator and myosin 1 linker 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Stark et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Stark et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6857 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa13993 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19830 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32986 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| stl413 | Allele with one deletion | Exon 2 | Unknown | TALEN |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR031943 | CARMIL, C-terminal domain |
| Domain | IPR041245 | CARMIL, pleckstrin homology domain |
| Family | IPR051279 | Protein Phosphatase 1 Regulatory and Actin Interaction Protein |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | CARMIL, C-terminal domain | CARMIL, pleckstrin homology domain | Leucine-rich repeat | Leucine-rich repeat domain superfamily | PH-like domain superfamily | Protein Phosphatase 1 Regulatory and Actin Interaction Protein |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0P0CP42 | InterPro | 1384 | ||||||
| UniProtKB:A0A8M1RSC9 | InterPro | 1348 | ||||||
| UniProtKB:A0A8M9Q4H0 | InterPro | 1327 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
carmil3-201
(1)
|
Ensembl | 786 nt | ||
| mRNA |
carmil3-203
(1)
|
Ensembl | 1,607 nt | ||
| mRNA |
carmil3-204
(1)
|
Ensembl | 7,450 nt | ||
| ncRNA |
lrrc16b-003
(1)
|
Ensembl | 726 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-204D18 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001317765 (1) | 7450 nt | ||
| Genomic | RefSeq:NW_018394507 (1) | 401442 nt | ||
| Polypeptide | UniProtKB:A0A0P0CP42 (1) | 1384 aa |
- Stark, B.C., Gao, Y., Sepich, D.S., Belk, L., Culver, M.A., Hu, B., Mekel, M., Ferris, W., Shin, J., Solnica-Krezel, L., Lin, F., Cooper, J.A. (2021) CARMIL3 is important for cell migration and morphogenesis during early development in zebrafish. Developmental Biology. 481:148-159
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Stark, B.C., Cooper, J.A. (2015) Differential expression of CARMIL-family genes during zebrafish development. Cytoskeleton (Hoboken, N.J.). 72(10):534-41
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