ZFIN is now using GRCz12tu for Genomic Data
Gene
kirrel1b
- ID
- ZDB-GENE-070912-173
- Name
- kirre like nephrin family adhesion molecule 1b
- Symbol
- kirrel1b Nomenclature History
- Previous Names
-
- kirrelb
- Neph1b (1)
- si:ch211-195h23.2
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cell adhesion molecule binding activity. Acts upstream of or within glomerular basement membrane development; podocyte development; and pronephric duct development. Predicted to be located in membrane. Predicted to be active in cell-cell junction and plasma membrane. Is expressed in brain and pronephric glomerulus. Human ortholog(s) of this gene implicated in nephrotic syndrome type 23. Orthologous to human KIRREL1 (kirre like nephrin family adhesion molecule 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Neumann-Haefelin et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephrotic syndrome type 23 | Alliance | Nephrotic syndrome, type 23 | 619201 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Domain | IPR013162 | CD80-like, immunoglobulin C2-set |
| Family | IPR051275 | Cellular adhesion and signaling domain-containing protein |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | CD80-like, immunoglobulin C2-set | Cellular adhesion and signaling domain-containing protein | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AQ03 | InterPro | 796 | ||||||||
| UniProtKB:A0A8M2BIN8 | InterPro | 784 | ||||||||
| UniProtKB:B3DHL7 | InterPro | 790 | ||||||||
| UniProtKB:A0A8M9QF61 | InterPro | 795 | ||||||||
| UniProtKB:A0A8M6Z878 | InterPro | 801 | ||||||||
| UniProtKB:A0A8M6Z0N3 | InterPro | 789 | ||||||||
| UniProtKB:A0A8M3B7X0 | InterPro | 783 | ||||||||
| UniProtKB:A0AB32TZL2 | InterPro | 778 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kirrel1b-201
(1)
|
Ensembl | 2,525 nt | ||
| mRNA |
kirrel1b-202
(1)
|
Ensembl | 3,919 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers