Gene
c8b
- ID
- ZDB-GENE-070912-163
- Name
- complement component 8, beta polypeptide
- Symbol
- c8b Nomenclature History
- Previous Names
-
- si:ch211-188c16.3
- wu:fi18d09
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to be involved in complement activation, classical pathway; cytolysis; and innate immune response. Predicted to localize to extracellular region and membrane attack complex. Is expressed in liver. Human ortholog(s) of this gene implicated in type II complement component 8 deficiency. Orthologous to human C8B (complement C8 beta chain).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 1 figure from Takada et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
type II complement component 8 deficiency | Alliance | C8 deficiency, type II | 613789 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR020863 | Membrane attack complex component/perforin domain, conserved site |
Conserved_site | IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
Domain | IPR020864 | Membrane attack complex component/perforin (MACPF) domain |
Domain | IPR048831 | Complement components C8A/B/C6, EGF-like domain |
Family | IPR001862 | Membrane attack complex component/perforin/complement C9 |
Homologous_superfamily | IPR036055 | LDL receptor-like superfamily |
Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
Repeat | IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
Domain Details Per Protein
Protein | Length | Complement components C8A/B/C6, EGF-like domain | LDL receptor-like superfamily | Low-density lipoprotein (LDL) receptor class A, conserved site | Low-density lipoprotein (LDL) receptor class A repeat | Membrane attack complex component/perforin/complement C9 | Membrane attack complex component/perforin domain, conserved site | Membrane attack complex component/perforin (MACPF) domain | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A8HAJ8
|
562 |
Interactions and Pathways
No data available
Plasmids
No data available