Gene
tagln
- ID
- ZDB-GENE-070912-1
- Name
- transgelin
- Symbol
- tagln Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization. Predicted to be located in cytoplasm. Predicted to be active in actin cytoskeleton. Is expressed in several structures, including artery; gut; hematopoietic stem cell; smooth muscle; and swim bladder bud. Orthologous to human TAGLN (transgelin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Calponin homology domain | Calponin-like | Calponin repeat | CH domain superfamily | Smooth muscle protein/calponin |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QHD6
|
206 | |||||
|
UniProtKB:Q0P4B4
|
199 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg1(tagln:cald1l-GFP) |
|
| 1 | (3) | |
| Tg2(tagln:cald1l-GFP) |
|
| 1 | (3) | |
| TgBAC(tagln:EGFP) |
|
| 1 | (5) | |
| Tg(tagln:CAAX-EGFP) |
|
| 1 | (3) | |
| Tg(tagln:ECR-GAL4) |
|
| 1 | Stratman et al., 2017 | |
| Tg(tagln:GFP) |
|
| 1 | (12) | |
| Tg(tagln:mCherry) |
|
| 1 | Elworthy et al., 2019 | |
| Tg(tagln:NLS-EGFP-2A-CFP-FTASE) |
|
| 1 | Stratman et al., 2017 | |
| Tg(tagln:NLS-mCherry) |
|
| 1 | Chhabria et al., 2019 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-144D13 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153186 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045467 (1) | 823 nt | ||
| Genomic | GenBank:CU469509 (2) | 105182 nt | ||
| Polypeptide | UniProtKB:A0A8M9QHD6 (1) | 206 aa |
- Zhang, J., Liang, Y., Zeng, W., Gao, X., Wang, D., Mai, C., Lin, Z., Zhao, H., Li, X. (2024) Inducing aortic aneurysm/dissection in zebrafish: evaluating the efficacy of β-Aminopropionic Nitrile as a model. Animal cells and systems. 28:849284-92
- Gao, Y., Jin, Q., Gao, C., Chen, Y., Sun, Z., Guo, G., Peng, J. (2022) Unraveling Differential Transcriptomes and Cell Types in Zebrafish Larvae Intestine and Liver. Cells. 11(20):
- Kapuria, S., Bai, H., Fierros, J., Huang, Y., Ma, F., Yoshida, T., Aguayo, A., Kok, F., Wiens, K.M., Yip, J.K., McCain, M.L., Pellegrini, M., Nagashima, M., Hitchcock, P.F., Mochizuki, N., Lawson, N.D., Harrison, M.M.R., Lien, C.L. (2022) Heterogeneous pdgfrβ+ cells regulate coronary vessel development and revascularization during heart regeneration. Development (Cambridge, England). 149(4):
- Leonard, E.V., Figueroa, R.J., Bussmann, J., Lawson, N.D., Amigo, J.D., Siekmann, A.F. (2022) Regenerating vascular mural cells in zebrafish fin blood vessels are not derived from pre-existing ones and differentially require pdgfrb signalling for their development. Development (Cambridge, England). 149(7)
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Zada, A., Zhao, Y., Halim, D., Windster, J., van der Linde, H.C., Glodener, J., Overkleeft, S., de Graaf, B.M., Verdijk, R.M., Brooks, A.S., Shepherd, I., Gao, Y., Burns, A.J., Hofstra, R.M.W., Alves, M.M. (2022) The long Filamin-a isoform is required for intestinal development and motility: implications for chronic intestinal pseudo-obstruction. Human molecular genetics. 32(1):151-160
- Fowler, G., French, D., Rose, A., Squires, P., Anecito da Silva, C., Ohata, S., Okamoto, H., French, C.R. (2021) Protein fucosylation is required for Notch dependent vascular integrity in zebrafish. Developmental Biology. 480:62-68
- Ogawa, M., Geng, F.S., Humphreys, D.T., Kristianto, E., Sheng, D.Z., Hui, S.P., Zhang, Y., Sugimoto, K., Nakayama, M., Zheng, D., Hesselson, D., Hodson, M.P., Bogdanovic, O., Kikuchi, K. (2021) Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish. Science (New York, N.Y.). 372:201-205
- Hou, Y., Lee, H.J., Chen, Y., Ge, J., Osman, F.O.I., McAdow, A.R., Mokalled, M.H., Johnson, S.L., Zhao, G., Wang, T. (2020) Cellular diversity of the regenerating caudal fin. Science advances. 6:eaba2084
- Chhabria, K., Vouros, A., Gray, C., MacDonald, R.B., Jiang, Z., Wilkinson, R.N., Plant, K., Vasilaki, E., Howarth, C., Chico, T.J.A. (2019) Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish. Disease models & mechanisms. 12(9):
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