Gene
nr4a3
- ID
- ZDB-GENE-070824-4
- Name
- nuclear receptor subfamily 4, group A, member 3
- Symbol
- nr4a3 Nomenclature History
- Previous Names
-
- NOR1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and glucocorticoid receptor binding activity. Involved in neutrophil homeostasis. Predicted to localize to nucleus and transcription regulator complex. Is expressed in basal plate midbrain region; brain; neurons; and spinal cord. Human ortholog(s) of this gene implicated in extraskeletal myxoid chondrosarcoma. Orthologous to human NR4A3 (nuclear receptor subfamily 4 group A member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017611 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Prince et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| extraskeletal myxoid chondrosarcoma | Alliance | Chondrosarcoma, extraskeletal myxoid | 612237 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR003070 | Orphan nuclear receptor |
| Family | IPR003073 | Orphan nuclear receptor, NURR type |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Orphan nuclear receptor | Orphan nuclear receptor, NURR type | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1L695
|
594 | |||||||
|
UniProtKB:E9QI47
|
186 | |||||||
|
UniProtKB:F1R8N1
|
594 | |||||||
|
UniProtKB:A0A0R4IMQ4
|
593 | |||||||
|
UniProtKB:I6LBI4
|
593 |
Interactions and Pathways
Plasmids
No data available