Gene
nr4a3
- ID
- ZDB-GENE-070824-4
- Name
- nuclear receptor subfamily 4, group A, member 3
- Symbol
- nr4a3 Nomenclature History
- Previous Names
-
- NOR1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear glucocorticoid receptor binding activity. Acts upstream of or within neutrophil homeostasis. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in basal plate midbrain region; brain; neurons; and spinal cord. Human ortholog(s) of this gene implicated in extraskeletal myxoid chondrosarcoma. Orthologous to human NR4A3 (nuclear receptor subfamily 4 group A member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017611 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Prince et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| extraskeletal myxoid chondrosarcoma | Alliance | Chondrosarcoma, extraskeletal myxoid | 612237 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR003070 | Nuclear receptor subfamily 4 group A member 1-3 |
| Family | IPR003073 | Nuclear receptor subfamily 4 group A member 2 |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Nuclear hormone receptor | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Nuclear receptor subfamily 4 group A member 1-3 | Nuclear receptor subfamily 4 group A member 2 | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AQK6 | InterPro | 686 | |||||||
| UniProtKB:F1R8N1 | InterPro | 594 |
Interactions and Pathways
Plasmids
No data available