Gene

hbegfb

ID
ZDB-GENE-070820-6
Name
heparin-binding EGF-like growth factor b
Symbol
hbegfb Nomenclature History
Previous Names
  • hbegf
  • zgc:165443
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to enable epidermal growth factor receptor binding activity and growth factor activity. Acts upstream of or within heart contraction. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in breast cancer; glomerulosclerosis; and perinatal necrotizing enterocolitis. Orthologous to human AREG (amphiregulin) and HBEGF (heparin binding EGF like growth factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from El-Brolosy et al., 2019
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Friedrichs et al., 2009
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hbegfb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Diphtheria, susceptibility to}
Associated With hbegfb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000742 EGF-like domain
Family IPR015497 Epidermal growth factor receptor ligand
Domain Details Per Protein
Protein Length EGF-like domain Epidermal growth factor receptor ligand
UniProtKB:A0A2R8RUB3 232
UniProtKB:Q6NY79 239
UniProtKB:A7E275 208
UniProtKB:F1QEL2 263
UniProtKB:F1QKE6 113
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations