Gene

lig4

ID
ZDB-GENE-070820-10
Name
ligase IV, DNA, ATP-dependent
Symbol
lig4 Nomenclature History
Previous Names
  • zgc:165595 (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; DNA binding activity; and DNA ligase (ATP) activity. Involved in double-strand break repair via nonhomologous end joining. Predicted to localize to DNA ligase IV complex and DNA-dependent protein kinase-DNA ligase 4 complex. Human ortholog(s) of this gene implicated in several diseases, including DNA ligase IV deficiency; colorectal cancer; malignant glioma; multiple myeloma; and prostate cancer. Orthologous to human LIG4 (DNA ligase 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Bian et al., 2019
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lig4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
DNA ligase IV deficiency Alliance LIG4 syndrome 606593
multiple myeloma Alliance {Multiple myeloma, resistance to} 254500
Associated With lig4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR016059 DNA ligase, ATP-dependent, conserved site
Domain IPR001357 BRCT domain
Domain IPR012308 DNA ligase, ATP-dependent, N-terminal
Domain IPR012309 DNA ligase, ATP-dependent, C-terminal
Domain IPR012310 DNA ligase, ATP-dependent, central
Domain IPR021536 DNA ligase IV domain
Domain IPR044125 DNA Ligase 4, adenylation domain
Family IPR000977 DNA ligase, ATP-dependent
Family IPR029710 DNA ligase 4
Homologous_superfamily IPR012340 Nucleic acid-binding, OB-fold
Homologous_superfamily IPR036420 BRCT domain superfamily
Homologous_superfamily IPR036599 DNA ligase, ATP-dependent, N-terminal domain superfamily
Domain Details Per Protein
Protein Length BRCT domain BRCT domain superfamily DNA ligase 4 DNA Ligase 4, adenylation domain DNA ligase, ATP-dependent DNA ligase, ATP-dependent, central DNA ligase, ATP-dependent, conserved site DNA ligase, ATP-dependent, C-terminal DNA ligase, ATP-dependent, N-terminal DNA ligase, ATP-dependent, N-terminal domain superfamily DNA ligase IV domain Nucleic acid-binding, OB-fold
UniProtKB:A7E283 909
UniProtKB:F1Q9E8 909
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations