Gene

mmp11b

ID

ZDB-GENE-070817-2

Name

matrix metallopeptidase 11b

Symbol

mmp11b Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular matrix. Is expressed in lens; myoseptum; pharyngeal arch 1; solid lens vesicle; and somite border. Orthologous to human MMP11 (matrix metallopeptidase 11).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Matchett et al., 2019

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mmp11b Human Ortholog

No data available

Associated With mmp11b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018486	Hemopexin, conserved site
Domain	IPR000585	Hemopexin-like domain
Domain	IPR001818	Peptidase M10, metallopeptidase
Domain	IPR006026	Peptidase, metallopeptidase
Domain	IPR033739	Peptidase M10A, catalytic domain
Family	IPR021190	Peptidase M10A
Homologous_superfamily	IPR024079	Metallopeptidase, catalytic domain superfamily
Homologous_superfamily	IPR036375	Hemopexin-like domain superfamily
Repeat	IPR018487	Hemopexin-like repeats

Domain Details Per Protein

Protein	Length	Hemopexin, conserved site	Hemopexin-like domain	Hemopexin-like domain superfamily	Hemopexin-like repeats	Metallopeptidase, catalytic domain superfamily	Peptidase M10A	Peptidase M10A, catalytic domain	Peptidase M10, metallopeptidase	Peptidase, metallopeptidase
UniProtKB:A0A8N7T826 InterPro	506

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	mmp11b-201 (1) Ensembl	Ensembl		1,590 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-mmp11b	polyclonal	mmp11b		Rabbit	IHC		2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations