Gene
tars2
- ID
- ZDB-GENE-070815-3
- Name
- threonyl-tRNA synthetase 2, mitochondrial
- Symbol
- tars2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 21. Orthologous to human TARS2 (threonyl-tRNA synthetase 2, mitochondrial).
- Genome Resources
-
- Alliance (1)
- Gene:100333765 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Accogli et al., 2023
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Accogli et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| combined oxidative phosphorylation deficiency 21 | Alliance | Combined oxidative phosphorylation deficiency 21 | 615918 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002314 | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) |
| Domain | IPR004095 | TGS |
| Domain | IPR004154 | Anticodon-binding |
| Domain | IPR006195 | Aminoacyl-tRNA synthetase, class II |
| Domain | IPR033728 | Threonine-tRNA ligase catalytic core domain |
| Domain | IPR047246 | Threonine-tRNA ligase, class IIa, anticodon-binding domain |
| Family | IPR002320 | Threonine-tRNA ligase, class IIa |
| Homologous_superfamily | IPR012675 | Beta-grasp domain superfamily |
| Homologous_superfamily | IPR018163 | Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily |
| Homologous_superfamily | IPR036621 | Anticodon-binding domain superfamily |
| Homologous_superfamily | IPR045864 | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class II | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) | Anticodon-binding | Anticodon-binding domain superfamily | Beta-grasp domain superfamily | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | TGS | Threonine-tRNA ligase catalytic core domain | Threonine-tRNA ligase, class IIa | Threonine-tRNA ligase, class IIa, anticodon-binding domain | Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PJQ9
|
687 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance