Gene
adamts9
- ID
- ZDB-GENE-070814-6
- Name
- ADAM metallopeptidase with thrombospondin type 1 motif, 9
- Symbol
- adamts9 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable metalloendopeptidase activity. Acts upstream of or within endocrine pancreas development and pancreas regeneration. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in several structures, including digestive system; gonad; immune system; lepidotrichium; and nervous system. Used to study scoliosis. Orthologous to human ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ecu8 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ecu9 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa9181 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9314 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17633 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18108 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30656 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35066 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41811 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41812 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-adamts9 | Capon et al., 2017 | |
| CRISPR2-adamts9 | (3) | |
| MO1-adamts9 | N/A | (2) |
| MO2-adamts9 | N/A | Choi et al., 2019 |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| scoliosis | adamts9stl316/stl316 | standard conditions | Gray et al., 2020 |
| scoliosis | adamts9stl756/stl756 | standard conditions | Gray et al., 2020 |
| scoliosis | adamts9stl336/stl336 | standard conditions | Gray et al., 2020 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ADAMTS/ADAMTS-like | ADAMTS/ADAMTS-like, cysteine-rich domain 3 | ADAMTS/ADAMTS-like, Spacer 1 | ADAMTS and ADAMTS-like | ADAMTS, cysteine-rich domain 2 | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin | Peptidase M12B, propeptide | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:G3G3K0 | InterPro | 1643 | ||||||||||
| UniProtKB:A0AB13ABE5 | InterPro | 1443 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adamts9-201
(1)
|
Ensembl | 10,402 nt | ||
| mRNA |
adamts9-202
(1)
|
Ensembl | 4,386 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(adamts9:EGFP,cryaa:EGFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-233C15 | ||
| Contained in | BAC | DKEY-88I22 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423670 (1) | 10352 nt | ||
| Genomic | GenBank:BX000993 (2) | 156591 nt | ||
| Polypeptide | UniProtKB:G3G3K0 (1) | 1643 aa |
- Carver, J.J., Amato, C.M., Yao, H., Zhu, Y. (2024) Adamts9 is required for the development of primary ovarian follicles and maintenance of female sex in zebrafish. Biology of reproduction. 111(5):1107-1128
- He, Y., Carver, J.J., Erickson, T., Le Pabic, P., Zhu, Y. (2023) Dynamic and broad expression of adamts9 in developing and adult zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(12):1449-1461
- Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595
- Carver, J.J., He, Y., Zhu, Y. (2021) Delay in primordial germ cell migration in adamts9 knockout zebrafish. Scientific Reports. 11:8545
- Gray, R.S., Gonzalez, R., Ackerman, S.D., Minowa, R., Griest, J.F., Bayrak, M.N., Troutwine, B., Canter, S., Monk, K.R., Sepich, D.S., Solnica-Krezel, L. (2020) Postembryonic screen for mutations affecting spine development in zebrafish. Developmental Biology. 471:18-33
- Wu, X.J., Liu, D.T., Chen, S., Hong, W., Zhu, Y. (2020) Impaired oocyte maturation and ovulation in membrane progestin receptor (mPR) knockouts in zebrafish. Molecular and Cellular Endocrinology. 511:110856
- Choi, Y.J., Halbritter, J., Braun, D.A., Schueler, M., Schapiro, D., Rim, J.H., Nandadasa, S., Choi, W.I., Widmeier, E., Shril, S., Körber, F., Sethi, S.K., Lifton, R.P., Beck, B.B., Apte, S.S., Gee, H.Y., Hildebrandt, F. (2019) Mutations of ADAMTS9 Cause Nephronophthisis-Related Ciliopathy. American journal of human genetics. 104:45-54
- Jansch Carter, N., Adam Roach, Z., Marie Byrnes, M., Zhu, Y. (2019) Adamts9 is Necessary for Ovarian Development in Zebrafish. General and comparative endocrinology. 277:130-140
- Liu, D.T., Hong, W.S., Chen, S.X., Zhu, Y. (2019) Upregulation of adamts9 by gonadotropin in preovulatory follicles of zebrafish. Molecular and Cellular Endocrinology. 499:110608
- Wu, X.J., Zhu, Y. (2019) Downregulation of nuclear progestin receptor (Pgr) and subfertility in double knockouts of progestin receptor membrane component 1 (pgrmc1) and pgrmc2 in zebrafish. General and comparative endocrinology. 285:113275
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