Gene
rnf111
- ID
- ZDB-GENE-070808-2
- Name
- ring finger protein 111
- Symbol
- rnf111 Nomenclature History
- Previous Names
-
- zmp:0000001195
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable SMAD binding activity; SUMO polymer binding activity; and ubiquitin protein ligase activity. Acts upstream of or within epiboly involved in gastrulation with mouth forming second and prechordal plate formation. Predicted to be located in PML body. Predicted to be active in cytoplasm and nucleus. Is expressed in neuroectoderm; polster; prechordal plate; and tail bud. Orthologous to human RNF111 (ring finger protein 111).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Bessarab et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Bessarab et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa7068 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20977 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20978 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa26971 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 4 of 4
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-rnf111 | N/A | Bessarab et al., 2015 |
| MO2-rnf111 | N/A | Bessarab et al., 2015 |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | E3 ubiquitin-protein ligase Arkadia, N-terminal | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | ZNRF3/Arkadia E3 ubiquitin-protein ligases |
|---|---|---|---|---|---|---|
| UniProtKB:F1QWE1 | InterPro | 1004 | ||||
| UniProtKB:N0A274 | InterPro | 1003 | ||||
| UniProtKB:R4KWC4 | InterPro | 1032 | ||||
| UniProtKB:A0A8M2BG80 | InterPro | 1033 |
1 - 4 of 4
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rnf111-201
(1)
|
Ensembl | 3,147 nt | ||
| mRNA |
rnf111-202
(1)
|
Ensembl | 3,144 nt | ||
| mRNA |
rnf111-203
(1)
|
Ensembl | 3,119 nt | ||
| mRNA |
rnf111-204
(1)
|
Ensembl | 3,231 nt | ||
| mRNA |
rnf111-205
(1)
|
Ensembl | 5,054 nt |
1 - 5 of 5
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-108M10 | ZFIN Curated Data | |
| Contained in | BAC | CH211-162M14 |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001281993 (1) | 3231 nt | ||
| Genomic | GenBank:AL935053 (1) | 138341 nt | ||
| Polypeptide | UniProtKB:A0A8M2BG80 (1) | 1033 aa |
- Comparative Orthology
- Alliance
- Bessarab, D.A., Mathavan, S., Jones, C.M., Ray Dunn, N. (2015) Zebrafish Rnf111 is encoded by multiple transcripts and is required for epiboly progression and prechordal plate development. Differentiation; research in biological diversity. 89(1-2):22-30
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466
1 - 3 of 3
Show