header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-070801-2
Gene Name: sirtuin 1
Gene Symbol: sirt1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: im:7148963

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have several functions, including NAD+ binding activity; p53 binding activity; and transcription corepressor activity. Involved in cell migration involved in sprouting angiogenesis; positive regulation of angiogenesis; and regulation of gliogenesis. Predicted to localize to the chromatin; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Is expressed in liver; male organism; and retina. Orthologous to human SIRT1 (sirtuin 1).
Genome Resources: Alliance (1),  Gene:797132 (1),  Ensembl(GRCz11):ENSDARG00000068064 (2)
GENE EXPRESSION
All Expression Data: 7 figures from 7 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7148963]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22388 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-sirt1 N/A 2
    MO2-sirt1 N/A 3
    MO3-sirt1 N/A 1
    DISEASE ASSOCIATED WITH sirt1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH sirt1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of gliogenesis (more)
    Cellular Component cytoplasm (more)
    Molecular Function NAD+ binding (more)
    GO Terms (all 17)
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sirt1 No data available
    MARKER RELATIONSHIPS
    sirt1 Encodes: [EST] IMAGE:7148963 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001334404 (1)
    Polypeptide UniProtKB:E7F8W3 (1) 710 aa
    Sequence Clusters UniGene:106228 (1)
    Sequence Information (all 16)
    ORTHOLOGY for sirt1 ( Chr: 13 )
    CITATIONS (35)