Gene

sirt1

ID
ZDB-GENE-070801-2
Name
sirtuin 1
Symbol
sirt1 Nomenclature History
Previous Names
  • im:7148963
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have several functions, including NAD+ binding activity; p53 binding activity; and transcription corepressor activity. Involved in cell migration involved in sprouting angiogenesis; positive regulation of angiogenesis; and regulation of gliogenesis. Predicted to localize to chromatin and nucleus. Is expressed in female organism; liver; male organism; and retina. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1).
Genome Resources
Note
None
Expression
All Expression Data
10 figures from 8 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sirt1 Human Ortholog
No data available
Associated With sirt1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR026590 Sirtuin family, catalytic core domain
Family IPR003000 Sirtuin family
Homologous_superfamily IPR026591 Sirtuin, catalytic core small domain superfamily
Homologous_superfamily IPR029035 DHS-like NAD/FAD-binding domain superfamily
Domain Details Per Protein
Protein Length DHS-like NAD/FAD-binding domain superfamily Sirtuin, catalytic core small domain superfamily Sirtuin family Sirtuin family, catalytic core domain
UniProtKB:W8CEW1 127
UniProtKB:E7F8W3 710
Transcripts
Genome Browsers
No data available
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-sirt1 polyclonal Rabbit
  • WB
Sigma-Aldrich
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations