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General Information
ZIRC
ZFIN ID: ZDB-GENE-070725-4
Gene Name: Janus kinase 3 (a protein tyrosine kinase, leukocyte)
Gene Symbol: jak3
Sequence Ontology ID : SO:0000704

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Previous Name: sb:eu418

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(Including Attributions)
Location: Chr: 8 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in T cell differentiation in thymus and natural killer cell differentiation. Predicted to  ...
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu418]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 4 (96.0h-120.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fb102 Indel Unknown Frameshift, Premature Stop TALEN
sa45312 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t25078 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 3 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH jak3 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    janus kinase-3 deficiency SCID, autosomal recessive, T-negative/B-positive type 600802
    DISEASE ASSOCIATED WITH jak3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process lymphocyte differentiation (more)
    Cellular Component cytoskeleton (more)
    Molecular Function ATP binding (more)
    GO Terms (all 24)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA jak3-002 (1) 563
    mRNA jak3-201 (1) 3410
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM jak3 No data available
    MARKER RELATIONSHIPS
    jak3Contained in: [BAC] DKEY-205D4 (order this)
    jak3Encodes: [EST] eu418 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_002663087 (1) 3641bp
    Genomic GenBank:CR936448 (1) 44724bp
    Select Tool
    Polypeptide UniProtKB:B0V237 (1) 1103aa
    Sequence Clusters UniGene:157976 (1)
    Sequence Information (all 14)
    ORTHOLOGY for jak3 (Chr: 8)
    CITATIONS (31)