Gene
gip
- ID
- ZDB-GENE-070720-10
- Name
- gastric inhibitory polypeptide
- Symbol
- gip Nomenclature History
- Previous Names
-
- zgc:165349
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Enables glucagon receptor binding activity. Acts upstream of or within response to starvation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in endocrine pancreas; intestine; and pancreas. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human GIP (gastric inhibitory polypeptide).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Gastric inhibitory polypeptide | Glucagon/GIP/secretin/VIP |
|---|---|---|---|
|
UniProtKB:A1DPK4
|
112 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(gip:iCre) |
|
| 1 | Mi et al., 2023 | |
| Tg(gip:Luciferase) |
|
| 1 | Chu et al., 2022 | |
| Tg(gip:TagRFP) |
|
| 1 | Chu et al., 2022 | |
| Tg(gip:Venus) |
|
| 1 | Chu et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-51N14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-220F10 | ZFIN Curated Data | |
| Has Artifact | cDNA | MGC:165349 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080059 (1) | 552 nt | ||
| Genomic | GenBank:CR383677 (1) | 164387 nt | ||
| Polypeptide | UniProtKB:A1DPK4 (1) | 112 aa |
- Du, Q., Shao, R., Wang, W., Zhang, H., Liao, X., Wang, Z., Yin, Z., Ai, Q., Mai, K., Tang, X., Wan, M. (2024) Vitamin D3 Regulates Energy Homeostasis under Short-Term Fasting Condition in Zebrafish (Danio Rerio). Nutrients. 16(9):
- Mi, J., Liu, K.C., Andersson, O. (2023) Decoding pancreatic endocrine cell differentiation and β cell regeneration in zebrafish. Science advances. 9:eadf5142
- Chu, L., Terasaki, M., Mattsson, C.L., Teinturier, R., Charbord, J., Dirice, E., Liu, K.C., Miskelly, M.G., Zhou, Q., Wierup, N., Kulkarni, R.N., Andersson, O. (2022) In vivo drug discovery for increasing incretin-expressing cells identifies DYRK inhibitors that reinforce the enteroendocrine system. Cell chemical biology. 29(9):1368-1380.e5
- Lavergne, A., Tarifeño-Saldivia, E., Pirson, J., Reuter, A.S., Flasse, L., Manfroid, I., Voz, M.L., Peers, B. (2020) Pancreatic and intestinal endocrine cells in zebrafish share common transcriptomic signatures and regulatory programmes. BMC Biology. 18:109
- Graham, G.V., Conlon, J.M., Abdel-Wahab, Y.H., Gault, V.A., Flatt, P.R. (2017) Evaluation of the insulinotropic and glucose-lowering actions of zebrafish GIP in mammalian systems: evidence for involvement of the GLP-1 receptor. Peptides. 100:182-189
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- On, J.S.W., Duan, C., Lee, L.T.O. (2015) Functional pairing of class B1 ligand-GPCR in cephalochordate provides evidence of the origin of PTH and PACAP/glucagonreceptor family. Molecular Biology and Evolution. 32(8):2048-59
- Park, C.R., Moon, M.J., Park, S., Kim, D.K., Cho, E.B., Millar, R.P., Hwang, J.I., and Seong, J.Y. (2013) A Novel Glucagon-Related Peptide (GCRP) and Its Receptor GCRPR Account for Coevolution of Their Family Members in Vertebrates. PLoS One. 8(6):e65420
- Musson, M.C., Jepeal, L.I., Finnerty, J.R., and Wolfe, M.M. (2011) Evolutionary expression of glucose-dependent-insulinotropic polypeptide (GIP). Regulatory peptides. 171:26-34
- Musson, M.C., Jepeal, L.I., Mabray, P.D., Zhdanova, I.V., Cardoso, W.V., and Wolfe, M.M. (2009) Expression of Glucose-Dependent-Insulinotropic Polypeptide (GIP) in the Zebrafish. American journal of physiology. Regulatory, integrative and comparative physiology. 297(6):R1803-R1812
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