Gene
agbl2
- ID
- ZDB-GENE-070719-6
- Name
- AGBL carboxypeptidase 2
- Symbol
- agbl2 Nomenclature History
- Previous Names
-
- CCP2 (1)
- zgc:165648
- zte25
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable metallocarboxypeptidase activity and tubulin binding activity. Predicted to be involved in protein side chain deglutamylation. Predicted to act upstream of or within proteolysis. Predicted to be located in ciliary basal body and cytosol. Predicted to be active in centriole and cytoplasm. Is expressed in brain; otic vesicle; pronephros; and sensory system. Orthologous to human AGBL2 (AGBL carboxypeptidase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Maimouni et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la023274Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa6806 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10896 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13465 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44328 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-agbl2 | N/A | (2) |
| MO2-agbl2 | N/A | Maimouni et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytosolic carboxypeptidase | Cytosolic carboxypeptidase, N-terminal | Peptidase M14, carboxypeptidase A |
|---|---|---|---|---|
|
UniProtKB:A0A0R4IYD6
|
1024 | |||
|
UniProtKB:A0A8M6Z500
|
1025 | |||
|
UniProtKB:A6H8T7
|
721 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-190O6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:165648 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001320148 (1) | 3465 nt | ||
| Genomic | GenBank:CR376836 (2) | 132156 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z500 (1) | 1025 aa |
- Maimouni, S., Lee, M.H., Sung, Y.M., Hall, M., Roy, A., Ouaari, C., Hwang, Y.S., Spivak, J., Glasgow, E., Swift, M., Patel, J., Cheema, A., Kumar, D., Byers, S. (2019) Tumor suppressor RARRES1 links tubulin deglutamylation to mitochondrial metabolism and cell survival. Oncotarget. 10:1606-1624
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Pathak, N., Austin-Tse, C.A., Liu, Y., Vasilyev, A., Drummond, I.A. (2014) Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function. Molecular biology of the cell. 25(12):1836-44
- Lyons, P.J., Sapio, M.R., and Fricker, L.D. (2013) Zebrafish cytosolic carboxypeptidases 1 and 5 are essential for embryonic development. The Journal of biological chemistry. 288(42):30454-62
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Sreenivasan, R., Cai, M., Bartfai, R., Wang, X., Christoffels, A., and Orban, L. (2008) Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. PLoS One. 3(3):e1791
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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