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ZIRC
ZFIN ID: ZDB-GENE-070719-1
Gene Name: sepiapterin reductase b
Gene Symbol: sprb    Nomenclature History

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Previous Name: zgc:194446

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have sepiapterin reductase activity. Predicted to be involved in tetrahydrobiopterin biosynthetic process. Human ortholog(s) of this gene implicated in dystonia and sepiapterin reductase deficiency. Orthologous to human SPR (sepiapterin reductase).
Genome Resources: Alliance (1),  Gene:795445 (1),  Ensembl(GRCz11):ENSDARG00000058553 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH sprb HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
sepiapterin reductase deficiency Alliance Dystonia, dopa-responsive, due to sepiapterin reductase deficiency 612716
DISEASE ASSOCIATED WITH sprb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process oxidation-reduction process (more)
Molecular Function sepiapterin reductase activity (more)
GO Terms (all 3)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002347 (1)
  • InterPro:IPR006393 (1)
  • InterPro:IPR036291 (1)
  • Pfam:PF00106 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sprb-201 (1)    Ensembl 1409
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sprb No data available
    MARKER RELATIONSHIPS
    sprb Contained in: [BAC] CH73-368O6 (1) (order this)
    sprb Encodes: [cDNA] MGC:194446 (1), MGC:194459 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001128790 (1)
    Genomic GenBank:CU469500 (1) 112831 bp
    Select Tool
    Polypeptide UniProtKB:B3DJY2 (1) 272 aa
    Sequence Clusters UniGene:116024 (1)
    Sequence Information (all 13)
    ORTHOLOGY for sprb ( Chr: 8 )
    CITATIONS (14)