Gene
alx4a
- ID
- ZDB-GENE-070712-3
- Name
- ALX homeobox 4a
- Symbol
- alx4a Nomenclature History
- Previous Names
-
- alx4 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in cranial neural crest; head; head mesenchyme; and pectoral fin bud. Human ortholog(s) of this gene implicated in colorectal cancer; craniosynostosis; frontonasal dysplasia 2; hepatocellular carcinoma; and parietal foramina. Orthologous to human ALX4 (ALX homeobox 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Jang et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| frontonasal dysplasia 2 | Alliance | Frontonasal dysplasia 2 | 613451 |
| parietal foramina | Alliance | Parietal foramina 2 | 609597 |
| {Craniosynostosis 5, susceptibility to} | 615529 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | OAR domain | Paired Homeobox Transcription Factors |
|---|---|---|---|---|---|---|
|
UniProtKB:E7FGP3
|
368 |
Interactions and Pathways
No data available
Plasmids
No data available