Gene

pole

ID

ZDB-GENE-070705-557

Name

polymerase (DNA directed), epsilon

Symbol

pole Nomenclature History

Previous Names

si:dkeyp-98c11.2

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have DNA binding activity; DNA-directed DNA polymerase activity; and single-stranded DNA 3'-5' exodeoxyribonuclease activity. Predicted to be involved in DNA metabolic process and mitotic cell cycle. Predicted to localize to epsilon DNA polymerase complex. Human ortholog(s) of this gene implicated in colorectal cancer. Is expressed in proliferative region. Orthologous to human POLE (DNA polymerase epsilon, catalytic subunit).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7165171 (13 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pole Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		FILS syndrome	615139
		IMAGE-I syndrome	618336
		{Colorectal cancer, susceptibility to, 12}	615083

Associated With pole Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006133	DNA-directed DNA polymerase, family B, exonuclease domain
Domain	IPR013697	DNA polymerase epsilon, catalytic subunit A, C-terminal
Family	IPR006172	DNA-directed DNA polymerase, family B
Family	IPR029703	DNA polymerase epsilon catalytic subunit
Homologous_superfamily	IPR012337	Ribonuclease H-like superfamily
Homologous_superfamily	IPR023211	DNA polymerase, palm domain superfamily
Homologous_superfamily	IPR036397	Ribonuclease H superfamily
Homologous_superfamily	IPR042087	DNA polymerase family B, thumb domain
Homologous_superfamily	IPR043502	DNA/RNA polymerase superfamily