Gene
sema4ba
- ID
- ZDB-GENE-070705-31
- Name
- sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ba
- Symbol
- sema4ba Nomenclature History
- Previous Names
-
- si:ch211-138h3.1
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Predicted to be involved in several processes, including axon guidance; neural crest cell migration; and semaphorin-plexin signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human SEMA4B (semaphorin 4B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Zheng et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa11879 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11928 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32209 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36655 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Plexin repeat | PSI domain | Sema domain | Sema domain superfamily | Semaphorin | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7F898 | InterPro | 830 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sema4ba-201
(1)
|
Ensembl | 2,493 nt | ||
| mRNA |
sema4ba-202
(1)
|
Ensembl | 2,912 nt | ||
| mRNA |
sema4ba-204
(1)
|
Ensembl | 2,952 nt | ||
| ncRNA |
sema4ba-002
(1)
|
Ensembl | 697 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-39K3 | ZFIN Curated Data | |
| Contained in | BAC | CH211-138H3 | ZFIN Curated Data | |
| Contained in | BAC | CH211-163J7 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128352 (1) | 2493 nt | ||
| Genomic | GenBank:CR812484 (1) | 149153 nt | ||
| Polypeptide | UniProtKB:E7F898 (1) | 830 aa |
- Yao, H., Shen, Y., Song, Z., Han, A., Chen, X., Zhang, Y., Hu, B. (2024) Rab11 promotes single Mauthner cell axon regeneration in vivo through axon guidance molecule Ntng2b. Experimental neurology. 374:114715
- Zheng, Y.Q., Suo, G.H., Liu, D., Li, H.Y., Wu, Y.J., Ni, H. (2022) Nexmifa Regulates Axon Morphogenesis in Motor Neurons in Zebrafish. Frontiers in molecular neuroscience. 15:848257
- Anbalagan, S., Gordon, L., Blechman, J., Matsuoka, R.L., Rajamannar, P., Wircer, E., Biran, J., Reuveny, A., Leshkowitz, D., Stainier, D.Y.R., Levkowitz, G. (2018) Pituicyte Cues Regulate the Development of Permeable Neuro-Vascular Interfaces. Developmental Cell. 47(6):711-726.e5
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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