Gene
pku300
- ID
- ZDB-GENE-070705-222
- Name
- pku300
- Symbol
- pku300 Nomenclature History
- Previous Names
-
- unm_pku300
- 182 (1)
- si:ch73-256j6.1
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Acts upstream of or within cell adhesion; heart development; and regulation of cell proliferation involved in heart valve morphogenesis. Is expressed in heart.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wang et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Wang et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-pku300 | N/A | Wang et al., 2013 |
| MO2-pku300 | N/A | Wang et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pku300-201
(1)
|
Ensembl | 1,038 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(kdrl:pku300) |
|
| 1 | (3) | |
| Tg(kdrl:pku300-mCherry) |
|
| 1 | (2) | |
| Tg(myl7:pku300) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-256J6 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| Genomic | GenBank:CU207311 | 92715 nt |
No data available
- Wang, X., Yu, Q., Wu, Q., Bu, Y., Changm, N.N., Yan, S., Zhou, X.H., Zhu, X., and Xiong, J.W. (2013) Genetic Interaction between pku300 and fbn2b Controls Endocardial Cell Proliferation and Valve Development in Zebrafish. Journal of Cell Science. 126(Pt 6):1381-91
- Fei, P., Yu, Z., Wang, X., Lu, P.J., Fu, Y., He, Z., Xiong, J., and Huang, Y. (2012) High dynamic range optical projection tomography (HDR-OPT). Optics express. 20(8):8824-8836
- Mellman, K., Huisken, J., Dinsmore, C., Hoppe, C., and Stainier, D.Y. (2012) Fibrillin-2b regulates endocardial morphogenesis in zebrafish. Developmental Biology. 372(1):111-119
- Chen, J.N., Haffter, P., Odenthal, J., Vogelsang, E., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development (Cambridge, England). 123:293-302
- Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
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