Gene

pigx

ID

ZDB-GENE-070705-212

Name

phosphatidylinositol glycan anchor biosynthesis, class X

Symbol

pigx Nomenclature History

Previous Names

si:ch73-159l23.2

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human PIGX (phosphatidylinositol glycan anchor biosynthesis class X).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa6688	Allele with one point mutation	Unknown	Splice Site	ENU
sa14619	Allele with one point mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa18479	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa37405	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With pigx Human Ortholog

No data available

Associated With pigx Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR013233	Glycosylphosphatidylinositol-mannosyltransferase I, PIG-X/PBN1
Family	IPR040039	Phosphatidylinositol-glycan biosynthesis class X protein

Domain Details Per Protein

Protein	Additional Resources	Length	Glycosylphosphatidylinositol-mannosyltransferase I, PIG-X/PBN1	Phosphatidylinositol-glycan biosynthesis class X protein
UniProtKB:A5WVS5	InterPro	243

Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 22

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	pigx-201 (1) Ensembl	Ensembl		876 nt	Select Tool ZFIN BLAST
mRNA	pigx-202 (1) Ensembl	Ensembl		869 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH73-159L23	CT027565	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001126436 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:CT027565 (1)	79954 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A5WVS5 (1)	243 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	PIGX	3	Ensembl:ENSG00000163964 Gene:54965 HGNC:26046 OMIM:610276	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Pigx	16	Ensembl:ENSMUSG00000023791 Gene:72084 MGI:1919334	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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