Gene

qdpra

ID
ZDB-GENE-070705-197
Name
quinoid dihydropteridine reductase a
Symbol
qdpra Nomenclature History
Previous Names
  • dhpra (1)
  • si:ch211-89f22.2
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to enable 6,7-dihydropteridine reductase activity; NADH binding activity; and NADPH binding activity. Acts upstream of or within L-phenylalanine metabolic process and melanin biosynthetic process. Predicted to be active in cytoplasm. Is expressed in eye; liver; melanoblast; and presumptive retinal pigmented epithelium. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia C and phenylketonuria. Orthologous to human QDPR (quinoid dihydropteridine reductase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Breuer et al., 2019
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Breuer et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
No data available
Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-qdpraN/ABreuer et al., 2019
1 - 1 of 1
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Human Disease
Associated With qdpra Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
BH4-deficient hyperphenylalaninemia C Alliance Hyperphenylalaninemia, BH4-deficient, C 261630
1 - 1 of 1
Associated With qdpra Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020904 Short-chain dehydrogenase/reductase, conserved site
Family IPR002347 Short-chain dehydrogenase/reductase SDR
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
1 - 3 of 3
Domain Details Per Protein
Protein Additional Resources Length NAD(P)-binding domain superfamily Short-chain dehydrogenase/reductase, conserved site Short-chain dehydrogenase/reductase SDR
UniProtKB:A7YT77 InterPro 237
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 14
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA qdpra-201 (1) Ensembl 4,656 nt
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-89F22
EncodescDNAMGC:136893ZFIN Curated Data
1 - 2 of 2
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanQDPR4
Phylogenetic tree (1)
Conserved genome location (synteny) (2)
Amino acid sequence comparison (2)
MouseQdpr5
Amino acid sequence comparison (2)
Phylogenetic tree (1)
Conserved genome location (synteny) (1)
Citations
1 - 7 of 7
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