Gene
mhc1zea
- ID
- ZDB-GENE-070705-176
- Name
- major histocompatibility complex class I ZEA
- Symbol
- mhc1zea Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to be involved in immune response. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in gill; intestine; kidney; liver; and spleen. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); bone marrow cancer (multiple); eye disease (multiple); and liver disease (multiple). Orthologous to several human genes including AZGP1 (alpha-2-glycoprotein 1, zinc-binding); HFE (homeostatic iron regulator); and HLA-A (major histocompatibility complex, class I, A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Dirscherl et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mhc1zea | China Zebrafish Resource Center (CZRC) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003006 | Immunoglobulin/major histocompatibility complex, conserved site |
| Domain | IPR001039 | MHC class I alpha chain, alpha1 alpha2 domains |
| Domain | IPR003597 | Immunoglobulin C1-set |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR011161 | MHC class I-like antigen recognition-like |
| Family | IPR050208 | Antigen-presenting and immune regulatory MHC class I-related |
| Homologous_superfamily | IPR011162 | MHC classes I/II-like antigen recognition protein |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
| Homologous_superfamily | IPR037055 | MHC class I-like antigen recognition-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Antigen-presenting and immune regulatory MHC class I-related | Immunoglobulin C1-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin/major histocompatibility complex, conserved site | MHC classes I/II-like antigen recognition protein | MHC class I alpha chain, alpha1 alpha2 domains | MHC class I-like antigen recognition-like | MHC class I-like antigen recognition-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7YP14 | InterPro | 326 | ||||||||||
| UniProtKB:A8E7F2 | InterPro | 350 | ||||||||||
| UniProtKB:A0A8M6YZS6 | InterPro | 349 | ||||||||||
| UniProtKB:A0A8M2BIB4 | InterPro | 345 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mhc1zea-202
(1)
|
Ensembl | 2,047 nt | ||
| mRNA |
mhc1zea-203
(1)
|
Ensembl | 1,020 nt | ||
| mRNA |
mhc1zea-204
(1)
|
Ensembl | 1,138 nt | ||
| ncRNA |
mhc1zea-002
(1)
|
Ensembl | 960 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-287J19 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162351 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001089550 (1) | 1377 nt | ||
| Genomic | GenBank:BX005416 (1) | 163197 nt | ||
| Polypeptide | UniProtKB:A8E7F2 (1) | 350 aa |
No data available
- McConnell, S.C., Hernandez, K.M., Andrade, J., de Jong, J.L.O. (2023) Immune gene variation associated with chromosome-scale differences among individual zebrafish genomes. Scientific Reports. 13:77777777
- Zhang, C., Zhao, Z., Jia, Y.J., Zhang, P.Q., Sun, Y., Zhou, Y.C., Wang, G.X., Zhu, B. (2023) Rationally Designed Self-Assembling Nanovaccines Elicit Robust Mucosal and Systemic Immunity against Rhabdovirus. ACS applied materials & interfaces. 16(1):228-244
- Honjo, Y., Takano, K., Ichinohe, T. (2020) Characterization of novel zebrafish MHC class I U lineage genes and their haplotype. Developmental and comparative immunology. 116:103952
- Zhang, C., Zhang, P.Q., Guo, S., Chen, G., Zhao, Z., Wang, G.X., Zhu, B. (2020) Application of Biomimetic Cell-Derived Nanoparticles with Mannose Modification as a Novel Vaccine Delivery Platform against Teleost Fish Viral Disease. ACS biomaterials science & engineering. 6:6770-6777
- Coronado, M., Solis, C.J., Hernandez, P.P., Feijóo, C.G. (2019) Soybean Meal-Induced Intestinal Inflammation in Zebrafish Is T Cell-Dependent and Has a Th17 Cytokine Profile. Frontiers in immunology. 10:610
- Wu, X.M., Hu, Y.W., Xue, N.N., Ren, S.S., Chen, S.N., Nie, P., Chang, M.X. (2017) Role of zebrafish NLRC5 in antiviral response and transcriptional regulation of MHC related genes. Developmental and comparative immunology. 68:58-68
- Liu, X., Xu, J., Zhang, H., Liu, Q., Xiao, J., Zhang, Y. (2016) Design and evaluation of an Edwardsiella tarda DNA vaccine co-encoding antigenic and adjuvant peptide. Fish & shellfish immunology. 59:189-195
- Dirscherl, H., Yoder, J.A. (2015) A nonclassical MHC class I U lineage locus in zebrafish with a null haplotypic variant. Immunogenetics. 67(9):501-13
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Dirscherl, H., and Yoder, J.A. (2014) Characterization of the Z lineage Major histocompatability complex class I genes in zebrafish. Immunogenetics. 66(3):185-98
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