Gene

dis3l2

ID

ZDB-GENE-070705-171

Name

DIS3 like 3'-5' exoribonuclease 2

Symbol

dis3l2 Nomenclature History

Previous Names

si:ch211-273k1.4

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have 3'-5'-exoribonuclease activity. Involved in pronephros development. Predicted to localize to P-body and exosome (RNase complex). Human ortholog(s) of this gene implicated in Perlman syndrome and nephroblastoma. Is expressed in pronephros. Orthologous to human DIS3L2 (DIS3 like 3'-5' exoribonuclease 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Astuti et al., 2012

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Astuti et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dis3l2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Perlman syndrome	Alliance	Perlman syndrome	267000

Associated With dis3l2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR022966	Ribonuclease II/R, conserved site
Domain	IPR001900	Ribonuclease II/R
Domain	IPR033771	Rrp44-like cold shock domain
Domain	IPR041505	Dis3-like cold-shock domain 2
Family	IPR028591	DIS3-like exonuclease 2
Family	IPR050180	RNR Ribonuclease
Homologous_superfamily	IPR012340	Nucleic acid-binding, OB-fold

Domain Details Per Protein

Protein	Length	Dis3-like cold-shock domain 2	DIS3-like exonuclease 2	Nucleic acid-binding, OB-fold	Ribonuclease II/R	Ribonuclease II/R, conserved site	RNR Ribonuclease	Rrp44-like cold shock domain
UniProtKB:E7F350 InterPro	995

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	dis3l2-201 (1) Ensembl	Ensembl		5,108 nt	Select Tool ZFIN BLAST
mRNA	dis3l2-202 (1) Ensembl	Ensembl		2,937 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations