dis3l2

ID

ZDB-GENE-070705-171

Name

DIS3 like 3'-5' exoribonuclease 2

Symbol

dis3l2 Nomenclature History

Previous Names

si:ch211-273k1.4

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable 3'-5'-RNA exonuclease activity. Acts upstream of or within pronephros development. Predicted to be located in cytoplasm. Predicted to be active in P-body. Is expressed in pronephros. Human ortholog(s) of this gene implicated in Perlman syndrome and nephroblastoma. Orthologous to human DIS3L2 (DIS3 like 3'-5' exoribonuclease 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dis3l2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Perlman syndrome	Alliance	Perlman syndrome	267000

Associated With dis3l2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR022966	Ribonuclease II/R, conserved site
Domain	IPR001900	Ribonuclease II/R
Domain	IPR033771	Rrp44-like cold shock domain
Domain	IPR041093	DIS3-like exonuclease 2-like, C-terminal
Domain	IPR041505	Dis3-like cold-shock domain 2
Family	IPR028591	DIS3-like exonuclease 2
Family	IPR050180	RNR Ribonuclease
Homologous_superfamily	IPR012340	Nucleic acid-binding, OB-fold