Gene
apoba
- ID
- ZDB-GENE-070702-4
- Name
- apolipoprotein Ba
- Symbol
- apoba Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have cholesterol transfer activity and low-density lipoprotein particle receptor binding activity. Predicted to be involved in several processes, including cholesterol homeostasis; lipoprotein transport; and triglyceride mobilization. Predicted to localize to several cellular components, including low-density lipoprotein particle; mature chylomicron; and very-low-density lipoprotein particle. Is expressed in heart; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Orthologous to human APOB (apolipoprotein B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6911942 (4 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial hypobetalipoproteinemia 1 | Alliance | Hypobetalipoproteinemia | 615558 |
| Hypercholesterolemia, familial, 2 | 144010 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001747 | Vitellogenin, N-terminal |
| Domain | IPR009454 | Lipid transport, open beta-sheet |
| Domain | IPR015255 | Vitellinogen, open beta-sheet |
| Family | IPR052418 | Apolipoprotein B |
| Homologous_superfamily | IPR011030 | Lipovitellin-phosvitin complex, superhelical domain |
| Homologous_superfamily | IPR015816 | Vitellinogen, beta-sheet N-terminal |
| Homologous_superfamily | IPR015819 | Lipid transport protein, beta-sheet shell |
Domain Details Per Protein
| Protein | Length | Apolipoprotein B | Lipid transport, open beta-sheet | Lipid transport protein, beta-sheet shell | Lipovitellin-phosvitin complex, superhelical domain | Vitellinogen, beta-sheet N-terminal | Vitellinogen, open beta-sheet | Vitellogenin, N-terminal |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7T7N7
|
4418 |
Interactions and Pathways
No data available
Plasmids
- Comparative Orthology
- Alliance