Gene

wrn

ID
ZDB-GENE-070702-2
Name
WRN RecQ like helicase
Symbol
wrn Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have 3'-5' DNA helicase activity and four-way junction helicase activity. Predicted to be involved in DNA geometric change; DNA metabolic process; and multicellular organism aging. Predicted to localize to chromosome; cytoplasm; and nucleoplasm. Human ortholog(s) of this gene implicated in Werner syndrome; breast cancer; coronary artery disease (multiple); diffuse scleroderma; and senile cataract. Orthologous to human WRN (WRN RecQ like helicase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With wrn Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Werner syndrome Alliance Werner syndrome 277700
Associated With wrn Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001650 Helicase, C-terminal
Domain IPR002121 HRDC domain
Domain IPR002562 3'-5' exonuclease domain
Domain IPR011545 DEAD/DEAH box helicase domain
Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
Domain IPR018982 RQC domain
Domain IPR029491 Helicase Helix-turn-helix domain
Domain IPR032284 ATP-dependent DNA helicase RecQ, zinc-binding domain
Family IPR004589 DNA helicase, ATP-dependent, RecQ type
Homologous_superfamily IPR010997 HRDC-like superfamily
Homologous_superfamily IPR012337 Ribonuclease H-like superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Homologous_superfamily IPR036397 Ribonuclease H superfamily
Domain Details Per Protein
Protein Length 3'-5' exonuclease domain ATP-dependent DNA helicase RecQ, zinc-binding domain DEAD/DEAH box helicase domain DNA helicase, ATP-dependent, RecQ type Helicase, C-terminal Helicase Helix-turn-helix domain Helicase superfamily 1/2, ATP-binding domain HRDC domain HRDC-like superfamily P-loop containing nucleoside triphosphate hydrolase Ribonuclease H-like superfamily Ribonuclease H superfamily RQC domain Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:A0A0R4IHR6 1436
UniProtKB:A0A0R4IT14 1387
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations