ZFIN is now using GRCz12tu for Genomic Data

Gene

dagla

ID

ZDB-GENE-070619-1

Name

diacylglycerol lipase, alpha

Symbol

dagla Nomenclature History

Previous Names

nsddr (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable lipoprotein lipase activity. Predicted to be involved in several processes, including arachidonate metabolic process; diacylglycerol catabolic process; and retrograde trans-synaptic signaling by endocannabinoid. Predicted to be active in dendrite membrane and postsynaptic membrane. Is expressed in brain and cranial ganglion. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human DAGLA (diacylglycerol lipase alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Martella et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dagla Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neuroocular syndrome 2, paroxysmal type	168885

Associated With dagla Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002921	Fungal lipase-type domain
Family	IPR052214	Diacylglycerol Lipase-Related
Homologous_superfamily	IPR029058	Alpha/Beta hydrolase fold

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8N7T821	InterPro	1051
UniProtKB:A0A8M3BAT1	InterPro	906
UniProtKB:E7F0B3	InterPro	1051
UniProtKB:A0AB32TZ29	InterPro	906
UniProtKB:A0AC58G379	InterPro	1051
UniProtKB:A0AC58G388	InterPro	906
UniProtKB:A0AC58G390	InterPro	879
UniProtKB:A0AC58G392	InterPro	743
UniProtKB:A0ACD6B5F4	InterPro	1051

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dagla-201 (1) Ensembl	Ensembl	5,259 nt	Select Tool ZFIN BLAST
mRNA	dagla-203 (1) Ensembl	Ensembl	5,848 nt	Select Tool ZFIN BLAST
mRNA	dagla-205 (1) Ensembl	Ensembl	336 nt	Select Tool ZFIN BLAST
mRNA	dagla-206 (1) Ensembl	Ensembl	5,334 nt	Select Tool ZFIN BLAST
ncRNA	dagla-002 (1) Ensembl	Ensembl	637 nt	Select Tool ZFIN BLAST
ncRNA	dagla-003 (1) Ensembl	Ensembl	846 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance

Citations