Gene
scn4ba
- ID
- ZDB-GENE-070615-18
- Name
- sodium channel, voltage-gated, type IV, beta a
- Symbol
- scn4ba Nomenclature History
- Previous Names
-
- scn4b.1 (1)
- zgc:165389
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable sodium channel regulator activity and transmembrane transporter binding activity. Predicted to be involved in cardiac conduction; cardiac muscle cell action potential; and regulation of ventricular cardiac muscle cell membrane repolarization. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in plasma membrane. Is expressed in atrium; brain; cardiac ventricle; eye; and musculature system. Human ortholog(s) of this gene implicated in long QT syndrome 10. Orthologous to human SCN4B (sodium voltage-gated channel beta subunit 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la012663Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| long QT syndrome 10 | Alliance | Atrial fibrillation, familial, 17 | 611819 |
| long QT syndrome 10 | Alliance | Long QT syndrome 10 | 611819 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin V-set domain | Myelin P0 protein-related |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q06W26 | InterPro | 232 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
scn4ba-201
(1)
|
Ensembl | 2,072 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-150G5 | ||
| Encodes | cDNA | MGC:165389 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194914 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194916 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077570 (1) | 2072 nt | ||
| Genomic | GenBank:BX901957 (1) | 175019 nt | ||
| Polypeptide | UniProtKB:Q06W26 (1) | 232 aa |
- Fang, C., Wang, P., Yu, D., Zhang, X., Gou, D., Liang, L., Bai, X., Xie, W., Li, H., Pu, J., Yao, Y., Wang, B., Ren, X., Ke, T., Tu, X., Xu, C., Wang, Q.K. (2022) Genome-Wide Association Study for Idiopathic Ventricular Tachyarrhythmias Identifies Key Role of CCR7 and PKN2 in Calcium Homeostasis and Cardiac Rhythm Maintenance. Circulation. Genomic and precision medicine. 15(5):e003603
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
- Benz, A., Kossack, M., Auth, D., Seyler, C., Zitron, E., Juergensen, L., Katus, H.A., Hassel, D. (2016) miR-19b Regulates Ventricular Action Potential Duration in Zebrafish. Scientific Reports. 6:36033
- Baraban, S.C., Dinday, M.T., and Hortopan, G.A. (2013) Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nature communications. 4:2410
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Bond, S.R., Wang, N., Leybaert, L., and Naus, C.C. (2012) Pannexin 1 Ohnologs in the Teleost Lineage. The Journal of membrane biology. 245(8):483-493
- Grayfer, L., and Belosevic, M. (2012) Indentification and molecular characterization of the interleukin-10 receptor 1 of the zebrafish (Danio rerio) and the goldfish (Carassius auratus L.). Developmental and comparative immunology. 36(2):408-17
- Chopra, S.S., Watanabe, H., Zhong, T.P., and Roden, D.M. (2007) Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: Implications for the evolution of electrical signaling in vertebrates. BMC Evolutionary Biology. 7(1):113
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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