Gene
nrg2a
- ID
- ZDB-GENE-070615-10
- Name
- neuregulin 2a
- Symbol
- nrg2a Nomenclature History
- Previous Names
-
- nrg2
- zgc:162973
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor binding activity. Acts upstream of or within several processes, including heart trabecula morphogenesis; neural crest cell migration; and skin epidermis development. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. Is expressed in brain; epidermis; heart; median fin fold; and somite. Orthologous to human NRG2 (neuregulin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb729 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| la011165Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021943Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mn0237Gt | Transgenic insertion | Unknown | Unknown | DNA | |
| sa23960 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| uab465 | Allele with multiple variants | Unknown | Unknown | CRISPR |
1 - 6 of 6
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR002154 | Neuregulin, C-terminal |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Family | IPR040180 | Neuregulin |
| Homologous_superfamily | IPR008993 | Tissue inhibitor of metalloproteinases-like, OB-fold |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like domain | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Neuregulin | Neuregulin, C-terminal | Tissue inhibitor of metalloproteinases-like, OB-fold |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3ATZ5 | InterPro | 639 | ||||||||||
| UniProtKB:A0A8M3AMA6 | InterPro | 587 | ||||||||||
| UniProtKB:A0A8M2B897 | InterPro | 633 | ||||||||||
| UniProtKB:A0A8M3B4T6 | InterPro | 606 | ||||||||||
| UniProtKB:A0A8M2B890 | InterPro | 710 | ||||||||||
| UniProtKB:A5D6U9 | InterPro | 488 | ||||||||||
| UniProtKB:A0A8M3ALK5 | InterPro | 637 | ||||||||||
| UniProtKB:A0A8M9PCF9 | InterPro | 644 | ||||||||||
| UniProtKB:A0AB13AA72 | InterPro | 710 | ||||||||||
| UniProtKB:A0AB32T7H8 | InterPro | 635 | ||||||||||
| UniProtKB:A0AB32T7H9 | InterPro | 712 | ||||||||||
| UniProtKB:A0AB32T8U8 | InterPro | 569 | ||||||||||
| UniProtKB:A0AB32T994 | InterPro | 565 | ||||||||||
| UniProtKB:A0AB32TA07 | InterPro | 563 | ||||||||||
| UniProtKB:A0AB32TAC4 | InterPro | 714 | ||||||||||
| UniProtKB:A0AB32TD22 | InterPro | 708 |
Interactions and Pathways
No data available
Plasmids
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001430844 (1) | 3518 nt | ||
| Genomic | GenBank:BX511240 (2) | 175187 nt | ||
| Polypeptide | UniProtKB:A0AB32TAC4 (1) | 714 aa |
- Qi, J., Rittershaus, A., Priya, R., Mansingh, S., Stainier, D.Y.R., Helker, C.S.M. (2022) Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafish. eLIFE. 11:
- Luo, H., Zhang, Y., Deng, Y., Li, L., Sheng, Z., Yu, Y., Lin, Y., Chen, X., Feng, P. (2021) Nxhl Controls Angiogenesis by Targeting VE-PTP Through Interaction With Nucleolin. Frontiers in cell and developmental biology. 9:728821
- Maugars, G., Nourizadeh-Lillabadi, R., Weltzien, F.A. (2020) New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts. Frontiers in endocrinology. 11:538196
- Priya, R., Allanki, S., Gentile, A., Mansingh, S., Uribe, V., Maischein, H.M., Stainier, D.Y.R. (2020) Tension heterogeneity directs form and fate to pattern the myocardial wall. Nature. 588(7836):130-134
- Dragojević, J., Mihaljević, I., Popović, M., Smital, T. (2019) Zebrafish (Danio rerio) Oat1 and Oat3 transporters and their interaction with physiological compounds. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 236:110309
- Abdul-Wajid, S., Demarest, B.L., Yost, H.J. (2018) Loss of embryonic neural crest derived cardiomyocytes causes adult onset hypertrophic cardiomyopathy in zebrafish. Nature communications. 9:4603
- Lai, J.K.H., Collins, M.M., Uribe, V., Jiménez-Amilburu, V., Günther, S., Maischein, H.M., Stainier, D.Y.R. (2018) The Hippo pathway effector Wwtr1 regulates cardiac wall maturation in zebrafish. Development (Cambridge, England). 145(10)
- Uribe, V., Ramadass, R., Dogra, D., Rasouli, S.J., Gunawan, F., Nakajima, H., Chiba, A., Reischauer, S., Mochizuki, N., Stainier, D.Y.R. (2018) In vivo analysis of cardiomyocyte proliferation during trabeculation.. Development (Cambridge, England). 145(14):
- Dogra, D., Ahuja, S., Kim, H.T., Rasouli, S.J., Stainier, D.Y.R., Reischauer, S. (2017) Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair. Nature communications. 8:1902
- Rasouli, S.J., Stainier, D.Y.R. (2017) Regulation of cardiomyocyte behavior in zebrafish trabeculation by Neuregulin 2a signaling. Nature communications. 8:15281
1 - 10 of 19
Show