Gene

nrg2a

ID

ZDB-GENE-070615-10

Name

neuregulin 2a

Symbol

nrg2a Nomenclature History

Previous Names

nrg2
zgc:162973

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have signaling receptor binding activity. Involved in several processes, including heart trabecula morphogenesis; neural crest cell migration; and skin epidermis development. Predicted to localize to extracellular space. Is expressed in brain; epidermis; heart; median fin fold; and somite. Orthologous to human NRG2 (neuregulin 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nrg2a Human Ortholog

No data available

Associated With nrg2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR002154	Neuregulin, C-terminal
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Family	IPR040180	Neuregulin
Homologous_superfamily	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	EGF-like domain	Immunoglobulin domain subtype	Immunoglobulin I-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin subtype 2	Neuregulin	Neuregulin, C-terminal	Tissue inhibitor of metalloproteinases-like, OB-fold
UniProtKB:A0A8M3ATZ5 InterPro	639
UniProtKB:A0A8M3AMA6 InterPro	587
UniProtKB:A0A8M2B897 InterPro	633
UniProtKB:A0A8M3B4T6 InterPro	606
UniProtKB:A0A8M2B890 InterPro	710
UniProtKB:A5D6U9 InterPro	488
UniProtKB:A0A8M3ALK5 InterPro	637
UniProtKB:A0A8M9PCF9 InterPro	644

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	nrg2a-201 (1) Ensembl	Ensembl	2,148 nt	Select Tool
mRNA	nrg2a-202 (1) Ensembl	Ensembl	1,697 nt	Select Tool ZFIN BLAST
mRNA	nrg2a-203 (1) Ensembl	Ensembl	1,497 nt	Select Tool ZFIN BLAST
mRNA	nrg2a-204 (1) Ensembl	Ensembl	1,717 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations