Gene

apln

ID
ZDB-GENE-070521-8
Name
apelin
Symbol
apln Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Enables apelin receptor binding activity. Involved in several processes, including coronary vasculature development; drinking behavior; and negative regulation of blood pressure. Acts upstream of or within with a positive effect on determination of heart left/right asymmetry and determination of liver left/right asymmetry. Acts upstream of or within ameboidal-type cell migration; circulatory system development; and response to hypoxia. Predicted to be located in extracellular space. Is expressed in several structures, including axial chorda mesoderm; axis; cardiovascular system; notochord; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human APLN (apelin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
12 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With apln Human Ortholog
No data available
Associated With apln Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR026155 Apelin
Domain Details Per Protein
Protein Length Apelin
UniProtKB:Q4TTN8 77
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations