Gene
apln
- ID
- ZDB-GENE-070521-8
- Name
- apelin
- Symbol
- apln Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Enables apelin receptor binding activity. Acts upstream of or within with a positive effect on determination of heart left/right asymmetry and determination of liver left/right asymmetry. Acts upstream of or within several processes, including cell migration involved in mesendoderm migration; circulatory system development; and mesodermal cell migration. Predicted to be located in extracellular region. Is expressed in several structures, including axial chorda mesoderm; axis; cardiovascular system; digestive system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human APLN (apelin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| mu267 | Allele with one delins | Exon 1 | Frameshift, Premature Stop | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-apln | (6) | |
| CRISPR2-apln | Zhu et al., 2019 | |
| CRISPR3-apln | Zhu et al., 2019 | |
| CRISPR4-apln | Zhu et al., 2019 | |
| MO1-apln | N/A | (4) |
| MO2-apln | N/A | Zeng et al., 2007 |
| MO3-apln | N/A | (4) |
| MO4-apln | N/A | Scott et al., 2007 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR026155 | Apelin |
Domain Details Per Protein
| Protein | Additional Resources | Length | Apelin |
|---|---|---|---|
| UniProtKB:Q4TTN8 | InterPro | 77 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(apln:Cre-ERT2) |
|
| 1 | Marín-Juez et al., 2019 | |
| TgBAC(apln:EGFP) |
|
| 1 | (5) | |
| Tg(hsp70l:apln) |
|
| 1 | Helker et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-61O11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001166124 (1) | 4451 nt | ||
| Genomic | GenBank:AL929104 (2) | 187365 nt | ||
| Polypeptide | UniProtKB:Q4TTN8 (1) | 77 aa |
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Nys, N., Khatib, A.M., Siegfried, G. (2024) Apela promotes blood vessel regeneration and remodeling in zebrafish. Scientific Reports. 14:37183718
- Wang, X., Zhao, J., Xu, J., Li, B., Liu, X., Xie, G., Duan, X., Liu, D. (2024) Noncaloric monosaccharides induce excessive sprouting angiogenesis in zebrafish via foxo1a-marcksl1a signal. eLIFE. 13:
- Ribeiro, A., Rebocho da Costa, M., de Sena-Tomás, C., Rodrigues, E.C., Quitéria, R., Maçarico, T., Rosa Santos, S.C., Saúde, L. (2023) Development and repair of blood vessels in the zebrafish spinal cord. Open Biology. 13:230103230103
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- El-Sammak, H., Yang, B., Guenther, S., Chen, W., Marín-Juez, R., Stainier, D.Y.R. (2022) A Vegfc-Emilin2a-Cxcl8a Signaling Axis Required for Zebrafish Cardiac Regeneration. Circulation research. 130(7):1014-1029
- Qi, J., Rittershaus, A., Priya, R., Mansingh, S., Stainier, D.Y.R., Helker, C.S.M. (2022) Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafish. eLIFE. 11:
- Bresciani, E., Carrington, B., Yu, K., Kim, E.M.K., Zhen, T., Guzman, V.S., Broadbridge, E., Bishop, K., Kirby, M., Harper, U., Wincovitch, S., Dell'Orso, S., Sartorelli, V., Sood, R., Liu, P.P. (2021) Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development. Blood advances. 5(23):4949-4962
- Lai, C.Y., Yeh, K.Y., Liu, B.F., Chang, T.M., Chang, C.H., Liao, Y.F., Liu, Y.W., Her, G.M. (2021) MicroRNA-21 Plays Multiple Oncometabolic Roles in Colitis-Associated Carcinoma and Colorectal Cancer via the PI3K/AKT, STAT3, and PDCD4/TNF-α Signaling Pathways in Zebrafish. Cancers. 13(21):
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
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