Gene

ghra

ID
ZDB-GENE-070509-1
Name
growth hormone receptor a
Symbol
ghra Nomenclature History
Previous Names
  • ghr
  • zgc:162141
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have several functions, including growth factor binding activity; growth hormone receptor activity; and peptide hormone binding activity. Predicted to be involved in cell surface receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to localize to cytosol; external side of plasma membrane; and growth hormone receptor complex. Is expressed in several structures, including lens; liver; notochord; pleuroperitoneal region; and yolk. Human ortholog(s) of this gene implicated in several diseases, including Laron syndrome; familial hypercholesterolemia; isolated growth hormone deficiency; osteoarthritis; and type 2 diabetes mellitus. Orthologous to human GHR (growth hormone receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ghra Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial hypercholesterolemia Alliance {Hypercholesterolemia, familial, modifier of} 143890
Laron syndrome Alliance Laron dwarfism 262500
Growth hormone insensitivity, partial 604271
Increased responsiveness to growth hormone 604271
Associated With ghra Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR003528 Long hematopoietin receptor, single chain, conserved site
Domain IPR003961 Fibronectin type III
Domain IPR015152 Growth hormone/erythropoietin receptor, ligand binding
Domain IPR025871 Growth hormone-binding protein
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Growth hormone-binding protein Growth hormone/erythropoietin receptor, ligand binding Immunoglobulin-like fold Long hematopoietin receptor, single chain, conserved site
UniProtKB:D0EUN7 232
UniProtKB:B4YQA3 570
UniProtKB:A4IG30 570
UniProtKB:A8WH89 570
UniProtKB:D0EUN6 231
UniProtKB:F1QFX3 570
UniProtKB:D0EUN5 177
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations