Gene

rasgrp3

ID
ZDB-GENE-070424-82
Name
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
Symbol
rasgrp3 Nomenclature History
Previous Names
  • zgc:162151
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have GTPase activator activity; calcium ion binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction and regulation of GTPase activity. Is expressed in blood island; central nervous system; and trunk vasculature. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human RASGRP3 (RAS guanyl releasing protein 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Gomez et al., 2009
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rasgrp3 Human Ortholog
No data available
Associated With rasgrp3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018247 EF-Hand 1, calcium-binding site
Domain IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
Domain IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
Domain IPR002048 EF-hand domain
Domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain IPR020454 Diacylglycerol/phorbol-ester binding
Family IPR008937 Ras-like guanine nucleotide exchange factor
Homologous_superfamily IPR011992 EF-hand domain pair
Homologous_superfamily IPR023578 Ras guanine nucleotide exchange factor domain superfamily
Homologous_superfamily IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
Homologous_superfamily IPR046349 C1-like domain superfamily
Domain Details Per Protein
Protein Length C1-like domain superfamily Diacylglycerol/phorbol-ester binding EF-Hand 1, calcium-binding site EF-hand domain EF-hand domain pair Protein kinase C-like, phorbol ester/diacylglycerol-binding domain Ras guanine-nucleotide exchange factor, catalytic domain superfamily Ras guanine nucleotide exchange factor domain superfamily Ras guanine-nucleotide exchange factors catalytic domain Ras-like guanine nucleotide exchange factor Ras-like guanine nucleotide exchange factor, N-terminal
UniProtKB:A4QNU6 708
UniProtKB:A0A8M2B4V9 708
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA rasgrp3-201 (1) Havana 3394 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations