Gene

ptpn13

ID

ZDB-GENE-070410-72

Name

protein tyrosine phosphatase non-receptor type 13

Symbol

ptpn13 Nomenclature History

Previous Names

wu:fb50g04
zgc:162319

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to enable phosphatidylinositol 3-kinase regulatory subunit binding activity and protein tyrosine phosphatase activity. Predicted to be involved in negative regulation of excitatory synapse assembly and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to act upstream of or within protein dephosphorylation and regulatory ncRNA-mediated gene silencing. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and nucleus. Is expressed in ovary. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); and colorectal cancer (multiple). Orthologous to human PTPN13 (protein tyrosine phosphatase non-receptor type 13).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ptpn13 Human Ortholog

No data available

Associated With ptpn13 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019747	FERM conserved site
Domain	IPR000242	Tyrosine-specific protein phosphatase, PTPase domain
Domain	IPR000299	FERM domain
Domain	IPR000387	Tyrosine-specific protein phosphatases domain
Domain	IPR001478	PDZ domain
Domain	IPR003595	Protein-tyrosine phosphatase, catalytic
Domain	IPR011019	KIND domain
Domain	IPR018979	FERM, N-terminal
Domain	IPR018980	FERM, C-terminal PH-like domain
Domain	IPR019748	FERM central domain
Domain	IPR019749	Band 4.1 domain
Family	IPR012153	Tyrosine-protein phosphatase non-receptor type 13
Family	IPR052074	Non-receptor Tyrosine-protein Phosphatases
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR014352	FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily	IPR029021	Protein-tyrosine phosphatase-like
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035963	FERM superfamily, second domain
Homologous_superfamily	IPR036034	PDZ superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A0R4IPR0	InterPro	2475
UniProtKB:A0A8M3AL92	InterPro	2432
UniProtKB:A0A8M3ATM7	InterPro	2460
UniProtKB:A0A0R4IWH3	InterPro	2317
UniProtKB:A0A8M2B8N1	InterPro	2480
UniProtKB:A0A8M3ALY6	InterPro	2455
UniProtKB:A0A8M3B4I1	InterPro	1353
UniProtKB:A0AB32T9N8	InterPro	2525
UniProtKB:A0AB32TAG6	InterPro	2520
UniProtKB:A0AB32TBJ6	InterPro	2477
UniProtKB:A0AB32TDC3	InterPro	2500
UniProtKB:A0AB32TFC9	InterPro	2505

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ptpn13-201 (1) Ensembl	Ensembl	420 nt	Select Tool ZFIN BLAST
mRNA	ptpn13-202 (1) Ensembl	Ensembl	8,288 nt	Select Tool ZFIN BLAST
mRNA	ptpn13-203 (1) Ensembl	Ensembl	7,814 nt	Select Tool ZFIN BLAST
mRNA	ptpn13-204 (1) Ensembl	Ensembl	941 nt	Select Tool ZFIN BLAST
mRNA	ptpn13-205 (1) Ensembl	Ensembl	4,340 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations