dnai2a

ID

ZDB-GENE-070410-46

Name

dynein, axonemal, intermediate chain 2a

Symbol

dnai2a Nomenclature History

Previous Names

zgc:162235

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in cilium movement and outer dynein arm assembly. Predicted to be located in cell projection; cytoplasm; and microtubule. Predicted to be part of outer dynein arm. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 9. Orthologous to human DNAI2 (dynein axonemal intermediate chain 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dnai2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary ciliary dyskinesia 9	Alliance	Ciliary dyskinesia, primary, 9, with or without situs inversus	612444

Associated With dnai2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Family	IPR050687	Dynein Intermediate Chain
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat