Gene

sfr1

ID

ZDB-GENE-070410-27

Name

SWI5-dependent homologous recombination repair protein 1

Symbol

sfr1 Nomenclature History

Previous Names

meir5
zgc:162162

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable transcription coactivator activity. Predicted to be involved in double-strand break repair via homologous recombination and positive regulation of DNA-templated transcription. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleus. Predicted to be part of Swi5-Sfr1 complex. Orthologous to human SFR1 (SWI5 dependent homologous recombination repair protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa35484	Allele with one point mutation	Unknown	Splice Site	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With sfr1 Human Ortholog

No data available

Associated With sfr1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR018468	SFR1/Mei5 family
Family	IPR042429	Swi5-dependent recombination DNA repair protein 1 homolog

Domain Details Per Protein

Protein	Additional Resources	Length	SFR1/Mei5 family	Swi5-dependent recombination DNA repair protein 1 homolog
UniProtKB:B7ZD04	InterPro	201
UniProtKB:A0AB32T6U3	InterPro	201

Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 13

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	sfr1-201 (1) Ensembl	Ensembl		1,221 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH211-223P8	AL929005	ZFIN Curated Data
Encodes	cDNA	MGC:162162	BC133892	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001082860 (1)	1116 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:AL929005 (2)	166364 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0AB32T6U3 (1)	201 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	SFR1	10	Ensembl:ENSG00000156384 Gene:119392 HGNC:29574 OMIM:616527	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)
Mouse	Sfr1	19	Ensembl:ENSMUSG00000025066 Gene:67788 MGI:1915038	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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