Gene
plod2
- ID
- ZDB-GENE-070326-1
- Name
- procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
- Symbol
- plod2 Nomenclature History
- Previous Names
-
- lh2 (1)
- zgc:101868
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Enables procollagen-lysine 5-dioxygenase activity. Acts upstream of or within several processes, including collagen biosynthetic process; collagen fibril organization; and skeletal muscle fiber development. Predicted to be located in endoplasmic reticulum membrane and rough endoplasmic reticulum. Predicted to be part of collagen trimer. Predicted to be active in several cellular components, including Golgi apparatus; endoplasmic reticulum; and extracellular space. Is expressed in several structures, including fin; fin fold actinotrichium; head; hypochord; and shield. Used to study Bruck syndrome. Orthologous to human PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bruck syndrome | Alliance | Bruck syndrome 2 | 609220 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Bruck syndrome | plod2sa1768/sa1768 | standard conditions | (2) |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001006 | Procollagen-lysine 5-dioxygenase, conserved site |
| Domain | IPR005123 | Oxoglutarate/iron-dependent dioxygenase domain |
| Domain | IPR006620 | Prolyl 4-hydroxylase, alpha subunit |
| Domain | IPR044861 | Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain |
| Family | IPR050757 | Collagen-modifying Glycosyltransferase 25 |
| Homologous_superfamily | IPR029044 | Nucleotide-diphospho-sugar transferases |
Domain Details Per Protein
| Protein | Additional Resources | Length | Collagen-modifying Glycosyltransferase 25 | Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain | Nucleotide-diphospho-sugar transferases | Oxoglutarate/iron-dependent dioxygenase domain | Procollagen-lysine 5-dioxygenase, conserved site | Prolyl 4-hydroxylase, alpha subunit |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A4U7F8 | InterPro | 733 | ||||||
| UniProtKB:A4U7F9 | InterPro | 754 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-plod2 | polyclonal | IgG | Rabbit |
|
Proteintech
|
2 |
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-208I6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:101868 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193648 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001089464 (1) | 3377 nt | ||
| Genomic | GenBank:CR790384 (2) | 175922 nt | ||
| Polypeptide | UniProtKB:A4U7F9 (1) | 754 aa |
- Diamond, K.M., Burtner, A.E., Siddiqui, D., Alvarado, K., Leake, S., Rolfe, S., Zhang, C., Kwon, R.Y., Maga, A.M. (2023) Examining craniofacial variation among crispant and mutant zebrafish models of human skeletal diseases. Journal of anatomy. 243(1):66-77
- Cao, Y., Xia, Y., Balowski, J.J., Ou, J., Song, L., Safi, A., Curtis, T., Crawford, G.E., Poss, K.D., Cao, J. (2022) Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration. Development (Cambridge, England). 149(4)
- Grivas, D., González-Rajal, Á., de la Pompa, J.L. (2021) Midkine-a Regulates the Formation of a Fibrotic Scar During Zebrafish Heart Regeneration. Frontiers in cell and developmental biology. 9:669439
- Gupta, V., Somarajan, B.I., Kaur, G., Gupta, S., Singh, R., Pradhan, D., Singh, H., Kaur, P., Sharma, A., Chawla, B., Pahuja, A., Ramachandran, R., Sharma, A. (2021) Exome sequencing identifies procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 mutations in primary congenital and juvenile glaucoma. Indian journal of ophthalmology. 69:2710-2716
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Watson, C.J., Monstad-Rios, A.T., Bhimani, R.M., Gistelinck, C., Willaert, A., Coucke, P., Hsu, Y.H., Kwon, R.Y. (2020) Phenomics-Based Quantification of CRISPR-Induced Mosaicism in Zebrafish. Cell systems. 10:275-286.e5
- Gistelinck, C., Kwon, R.Y., Malfait, F., Symoens, S., Harris, M.P., Henke, K., Hawkins, M.B., Fisher, S., Sips, P., Guillemyn, B., Bek, J.W., Vermassen, P., De Saffel, H., Witten, P.E., Weis, M., De Paepe, A., Eyre, D.R., Willaert, A., Coucke, P.J. (2018) Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies. Proceedings of the National Academy of Sciences of the United States of America. 115(34):E8037-E8046
- Hur, M., Gistelinck, C.A., Huber, P., Lee, J., Thompson, M.H., Monstad-Rios, A.T., Watson, C.J., McMenamin, S.K., Willaert, A., Parichy, D.M., Coucke, P., Kwon, R.Y. (2017) microCT-based phenomics in the zebrafish skeleton reveals virtues of deep phenotyping in a distributed organ system. eLIFE. 6
- Gistelinck, C., Eckhard Witten, P., Huysseune, A., Symoens, S., Malfait, F., Larionova, D., Simoens, P., Dierick, M., Van Hoorebeke, L., De Paepe, A., Kwon, R.Y., Weis, M., Eyre, D.R., Willaert, A., Coucke, P.J. (2016) Loss of Type I Collagen Telopeptide Lysyl Hydroxylation Causes Musculoskeletal Abnormalities in a Zebrafish Model of Bruck Syndrome. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 31(11):1930-1942
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
1 - 10 of 13
Show