Gene

plod2

ID

ZDB-GENE-070326-1

Name

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

Symbol

plod2 Nomenclature History

Previous Names

lh2 (1)
zgc:101868

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Enables procollagen-lysine 5-dioxygenase activity. Acts upstream of or within several processes, including collagen biosynthetic process; collagen fibril organization; and skeletal muscle fiber development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of collagen trimer. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including fin; hypochord; intestine; shield; and skeletal system. Used to study Bruck syndrome. Orthologous to human PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 13 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With plod2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Bruck syndrome	Alliance	Bruck syndrome 2	609220

Associated With plod2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Bruck syndrome	plod2^{sa1768/sa1768}	standard conditions	(2)

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001006	Procollagen-lysine 5-dioxygenase, conserved site
Domain	IPR005123	Oxoglutarate/iron-dependent dioxygenase domain
Domain	IPR006620	Prolyl 4-hydroxylase, alpha subunit
Domain	IPR044861	Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain
Family	IPR050757	Collagen-modifying Glycosyltransferase 25
Homologous_superfamily	IPR029044	Nucleotide-diphospho-sugar transferases

Domain Details Per Protein

Protein	Length	Collagen-modifying Glycosyltransferase 25	Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain	Nucleotide-diphospho-sugar transferases	Oxoglutarate/iron-dependent dioxygenase domain	Procollagen-lysine 5-dioxygenase, conserved site	Prolyl 4-hydroxylase, alpha subunit
UniProtKB:A4U7F8 InterPro	733
UniProtKB:A4U7F9 InterPro	754

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	plod2-201 (1) Ensembl	Ensembl	3,370 nt	Select Tool ZFIN BLAST
mRNA	plod2-202 (1) Ensembl	Ensembl	3,307 nt	Select Tool ZFIN BLAST
ncRNA	plod2-003 (1) Ensembl	Ensembl	1,190 nt	Select Tool ZFIN BLAST
ncRNA	plod2-004 (1) Ensembl	Ensembl	645 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-plod2	polyclonal	plod2	IgG	Rabbit	WB	Proteintech	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations