ZFIN ID: ZDB-GENE-070319-1
Gene Name: recombination signal binding protein for immunoglobulin kappa J region b
Gene Symbol: rbpjb    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: Su(H)2 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have RNA polymerase II repressing transcription factor binding activity and sequence-specific DNA binding activity. Involved in several processes, including animal organ development; blood vessel development; and somitogenesis. Predicted to localize to MAML1-RBP-Jkappa- ICN1 complex; nucleus; and transcription factor complex. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Is expressed in eye and head. Orthologous to human RBPJ (recombination signal binding protein for immunoglobulin kappa J region).
Genome Resources: Alliance (1),  Gene:563306 (1),  Ensembl(GRCz11):ENSDARG00000052091 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa8403 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34217 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-rbpjb N/A 2
    MO2-rbpjb N/A 2
    MO4-rbpja,rbpjb N/A 32
    MO5-rbpja,rbpjb N/A 4
    MO6-rbpjb N/A 1
    DISEASE ASSOCIATED WITH rbpjb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Adams-Oliver syndrome Alliance Adams-Oliver syndrome 3 614814
    DISEASE ASSOCIATED WITH rbpjb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process adrenal gland development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 24)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rbpjb-201 (1)    Ensembl 3196
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rbpjb No data available
    MARKER RELATIONSHIPS
    rbpjb Contained in: [BAC] CH211-234B14 (1), DKEY-39M14 (1) (order this), DKEYP-78B3 (1)
    rbpjb Encodes: [cDNA] MGC:171981 (1), MGC:194599 (1), MGC:194601 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001083551 (1) 3156 nt
    Genomic GenBank:BX664612 (1) 186965 nt
    Select Tool
    Polypeptide UniProtKB:A3QQ82 (1) 491 aa
    Sequence Information (all 25)
    ORTHOLOGY for rbpjb ( Chr: 7 )
    CITATIONS (59)