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Gene

rbpjb

ID
ZDB-GENE-070319-1
Name
recombination signal binding protein for immunoglobulin kappa J region b
Symbol
rbpjb Nomenclature History
Previous Names
  • Su(H)2 (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; blood vessel development; and somitogenesis. Predicted to be located in nucleus. Predicted to be part of MAML1-RBP-Jkappa- ICN1 complex. Is expressed in eye and head. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Orthologous to human RBPJ (recombination signal binding protein for immunoglobulin kappa J region).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Echeverri et al., 2007
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rbpjb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Adams-Oliver syndrome Alliance Adams-Oliver syndrome 3 614814
Associated With rbpjb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR015350 Beta-trefoil DNA-binding domain
Domain IPR015351 RBP-J/Cbf11/Cbf12, DNA binding
Domain IPR038007 RBP-Jkappa, IPT domain
Family IPR040159 Suppressor of hairless-like
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR014756 Immunoglobulin E-set
Homologous_superfamily IPR036358 Beta-trefoil domain superfamily
Homologous_superfamily IPR037095 RBP-J/Cbf11/Cbf12, DNA binding domain superfamily
Domain Details Per Protein
Protein Length Beta-trefoil DNA-binding domain Beta-trefoil domain superfamily Immunoglobulin E-set Immunoglobulin-like fold p53-like transcription factor, DNA-binding RBP-J/Cbf11/Cbf12, DNA binding RBP-J/Cbf11/Cbf12, DNA binding domain superfamily RBP-Jkappa, IPT domain Suppressor of hairless-like
UniProtKB:A4FTT4 491
UniProtKB:A3QQ82 491
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations