Gene
ackr3a
- ID
- ZDB-GENE-070301-5
- Name
- atypical chemokine receptor 3a
- Symbol
- ackr3a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Acts upstream of or within chemotaxis and posterior lateral line neuromast primordium migration. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including midbrain hindbrain boundary neural rod; midbrain neural rod; midbrain neural tube; presumptive endoderm; and rhombomere. Orthologous to human ACKR3 (atypical chemokine receptor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Venkiteswaran et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa34640 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-ackr3a | N/A | Venkiteswaran et al., 2013 |
| MO2-ackr3a | N/A | Venkiteswaran et al., 2013 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Oculomotor-abducens synkinesis | 619215 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Atypical chemokine receptor 3 | C-C chemokine receptor type 1-9-like | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8PYR8 | InterPro | 360 | ||||
| UniProtKB:A0A8M2BEZ8 | InterPro | 403 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ackr3a-201
(1)
|
Ensembl | 2,556 nt | ||
| mRNA |
ackr3a-202
(1)
|
Ensembl | 1,583 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-74A11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001144814 (1) | 1583 nt | ||
| Genomic | GenBank:CR545476 (1) | 202562 nt | ||
| Polypeptide | UniProtKB:A0A8M2BEZ8 (1) | 403 aa |
- Comparative Orthology
- Alliance
- Tang, D., Lu, Y., Zuo, N., Yan, R., Wu, C., Wu, L., Liu, S., He, Y. (2021) The H3K27 demethylase controls the lateral line embryogenesis of zebrafish. Cell biology and toxicology. 39(3):1137-1152
- Lombó, M., Getino-Álvarez, L., Depincé, A., Labbé, C., Herráez, M.P. (2019) Embryonic Exposure to Bisphenol A Impairs Primordial Germ Cell Migration without Jeopardizing Male Breeding Capacity. Biomolecules. 9(8)
- Sommer, F., Torraca, V., Kamel, S.M., Lombardi, A., Meijer, A.H. (2019) Frontline Science: Antagonism between regular and atypical Cxcr3 receptors regulates macrophage migration during infection and injury in zebrafish. Journal of Leukocyte Biology. 107(2):185-203
- Tobia, C., Chiodelli, P., Barbieri, A., Buraschi, S., Ferrari, E., Mitola, S., Borsani, G., Guerra, J., Presta, M. (2019) Atypical Chemokine Receptor 3 Generates Guidance Cues for CXCL12-Mediated Endothelial Cell Migration. Frontiers in immunology. 10:1092
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Moissoglu, K., Majumdar, R., and Parent, C.A. (2014) Cell migration: sinking in a gradient. Current biology : CB. 24(1):R23-R25
- Lewellis, S.W., Nagelberg, D., Subedi, A., Staton, A., Leblanc, M., Giraldez, A., and Knaut, H. (2013) Precise SDF1-mediated cell guidance is achieved through ligand clearance and microRNA-mediated decay. The Journal of cell biology. 200(3):337-355
- Nomiyama, H., Osada, N., and Yoshie, O. (2013) Systematic classification of vertebrate chemokines based on conserved synteny and evolutionary history. Genes to cells : devoted to molecular & cellular mechanisms. 18(1):1-16
- Venkiteswaran, G., Lewellis, S.W., Wang, J., Reynolds, E., Nicholson, C., and Knaut, H. (2013) Generation and Dynamics of an Endogenous, Self-Generated Signaling Gradient across a Migrating Tissue. Cell. 155(3):674-687
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