Gene
gpx3
- ID
- ZDB-GENE-070222-3
- Name
- glutathione peroxidase 3
- Symbol
- gpx3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable glutathione peroxidase activity. Acts upstream of or within swimming behavior. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; cerebral infarction; gastrointestinal system cancer (multiple); multiple myeloma; and type 2 diabetes mellitus. Orthologous to several human genes including GPX3 (glutathione peroxidase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Restuadi et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1478 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Glutathione peroxidase | Glutathione peroxidase active site | Thioredoxin-like superfamily |
|---|---|---|---|---|---|
| UniProtKB:A0A8M1NIR5 | InterPro | 222 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-174H24 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001137555 (1) | 5291 nt | ||
| Genomic | GenBank:CT997810 (2) | 136529 nt | ||
| Polypeptide | UniProtKB:A0A8M1NIR5 (1) | 222 aa |
- Lai, S., Shiraishi, H., Sebastian, W.A., Shimizu, N., Umeda, R., Ikeuchi, M., Kiyota, K., Takeno, T., Miyazaki, S., Yano, S., Shimada, T., Yoshimura, A., Hanada, R., Hanada, T. (2024) Effect of nonsense-mediated mRNA decay factor SMG9 deficiency on premature aging in zebrafish. Communications biology. 7:654654
- Zhao, L., Wang, L.F., Wang, Y.C., Liu, A., Xiao, Q.W., Hu, M.C., Sun, M.Z., Hao, H.Y., Gao, Q., Zhao, X., Chen, D.Y. (2024) Deficiency of P2RY11 causes narcolepsy and attenuates the recruitment of neutrophils and macrophages in the inflammatory response in zebrafish. Cell biology and toxicology. 40:3636
- Novichkova, E., Nayak, S., Boussiba, S., Gopas, J., Zilberg, D., Khozin-Goldberg, I. (2023) Dietary Application of the Microalga Lobosphaera incisa P127 Reduces Severity of Intestinal Inflammation, Modulates Gut-Associated Gene Expression and Microbiome in the Zebrafish Model of IBD. Molecular Nutrition & Food Research. 67(6):e2200253
- Xu, H., Mao, X., Nie, Z., Li, Y. (2023) Oxr1a prevents the premature ovarian failure by regulating oxidative stress and mitochondrial function in zebrafish. Free radical biology & medicine. 203:102-113
- Restuadi, R., Steyn, F.J., Kabashi, E., Ngo, S.T., Cheng, F.F., Nabais, M.F., Thompson, M.J., Qi, T., Wu, Y., Henders, A.K., Wallace, L., Bye, C.R., Turner, B.J., Ziser, L., Mathers, S., McCombe, P.A., Needham, M., Schultz, D., Kiernan, M.C., van Rheenen, W., van den Berg, L.H., Veldink, J.H., Ophoff, R., Gusev, A., Zaitlen, N., McRae, A.F., Henderson, R.D., Wray, N.R., Giacomotto, J., Garton, F.C. (2022) Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1. Genome Medicine. 14:7
- Zhao, Y., Wang, H., Duah, P.A., Retyunskiy, V., Liu, Y., Chen, G. (2022) Zinc pyrithione (ZPT) -induced embryonic toxicogenomic responses reveal involvement of oxidative damage, apoptosis, endoplasmic reticulum (ER) stress and autophagy. Aquatic toxicology (Amsterdam, Netherlands). 248:106195
- Xu, H., Wang, G., Chi, Y.Y., Kou, Y.X., Li, Y. (2021) Expression profiling and functional characterization of the duplicated Oxr1b gene in zebrafish. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 39:100857
- Dos Santos, M.M., de Macedo, G.T., Prestes, A.S., Ecker, A., Müller, T.E., Leitemperger, J., Fontana, B.D., Ardisson-Araújo, D.M.P., Rosemberg, D.B., Barbosa, N.V. (2020) Modulation of Redox and insulin signaling underlie the anti-hyperglycemic and antioxidant effects of diphenyl diselenide in zebrafish. Free radical biology & medicine. 158:20-31
- Hughes, G.L., Lones, M.A., Bedder, M., Currie, P.D., Smith, S.L., Pownall, M.E. (2020) Machine learning discriminates a movement disorder in a zebrafish model of Parkinson's disease. Disease models & mechanisms. 13(10):
- Nayak, S., Al Ashhab, A., Zilberg, D., Khozin-Goldberg, I. (2020) Dietary Supplementation with Omega-6 LC-PUFA-Rich Microalgae Regulates Mucosal Immune Response and Promotes Microbial Diversity in the Zebrafish Gut. Biology. 9(6):
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