Gene
tbx3a
- ID
- ZDB-GENE-070209-80
- Name
- T-box transcription factor 3a
- Symbol
- tbx3a Nomenclature History
- Previous Names
-
- tbx-b
- tbx3
- tbx3b
- tbxb
- zgc:158110 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in embryonic heart tube development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in ulnar-mammary syndrome. Is expressed in atrioventricular canal; heart tube; notochord; pectoral fin; and retina. Orthologous to human TBX3 (T-box transcription factor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Ribeiro et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ulnar-mammary syndrome | Alliance | Ulnar-mammary syndrome | 181450 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018186 | Transcription factor, T-box, conserved site |
| Domain | IPR022582 | T-box transcription factor 2/3, transcription activation domain |
| Domain | IPR046360 | T-box transcription factor, DNA-binding domain |
| Domain | IPR048387 | T-box transcription factor 2/3, repressor domain |
| Family | IPR001699 | T-box transcription factor |
| Family | IPR002070 | Transcription factor, Brachyury |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR036960 | T-box superfamily |
Domain Details Per Protein
| Protein | Length | p53-like transcription factor, DNA-binding domain superfamily | T-box superfamily | T-box transcription factor | T-box transcription factor 2/3, repressor domain | T-box transcription factor 2/3, transcription activation domain | T-box transcription factor, DNA-binding domain | Transcription factor, Brachyury | Transcription factor, T-box, conserved site |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B8JKS6
|
689 |
Interactions and Pathways
No data available
Plasmids
No data available