ZFIN is now using GRCz12tu for Genomic Data
Gene
sh2b1
- ID
- ZDB-GENE-070209-188
- Name
- SH2B adaptor protein 1
- Symbol
- sh2b1 Nomenclature History
- Previous Names
-
- zgc:158474
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in plasma membrane. Is expressed in nervous system; pectoral fin; and pharyngeal arch. Orthologous to human SH2B1 (SH2B adaptor protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Peng et al., 2025
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR015012 | Phenylalanine zipper |
| Domain | IPR035057 | SH2B1, SH2 domain |
| Family | IPR030523 | SH2B adapter protein |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR036290 | Phenylalanine zipper superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Phenylalanine zipper | Phenylalanine zipper superfamily | PH-like domain superfamily | Pleckstrin homology domain | SH2B1, SH2 domain | SH2B adapter protein | SH2 domain | SH2 domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A2RUZ0 | InterPro | 906 | ||||||||
| UniProtKB:A0A8M2BAY6 | InterPro | 858 | ||||||||
| UniProtKB:A0AC58ITS2 | InterPro | 858 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers