ZFIN is now using GRCz12tu for Genomic Data
Gene
sos1
- ID
- ZDB-GENE-070209-128
- Name
- son of sevenless homolog 1 (Drosophila)
- Symbol
- sos1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be part of nucleosome. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 4; atrial heart septal defect; gingival fibromatosis; and pulmonary valve stenosis. Orthologous to human SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| gingival fibromatosis | Alliance | Fibromatosis, gingival, 1 | 135300 |
| Noonan syndrome 4 | Alliance | Noonan syndrome 4 | 610733 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019804 | Ras guanine-nucleotide exchange factor, conserved site |
| Domain | IPR001895 | Ras guanine-nucleotide exchange factors catalytic domain |
| Family | IPR002119 | Histone H2A |
| Family | IPR008937 | Ras-like guanine nucleotide exchange factor |
| Homologous_superfamily | IPR009072 | Histone-fold |
| Homologous_superfamily | IPR023578 | Ras guanine nucleotide exchange factor domain superfamily |
| Homologous_superfamily | IPR036964 | Ras guanine-nucleotide exchange factor, catalytic domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Histone-fold | Histone H2A | Ras guanine-nucleotide exchange factor, catalytic domain superfamily | Ras guanine-nucleotide exchange factor, conserved site | Ras guanine nucleotide exchange factor domain superfamily | Ras guanine-nucleotide exchange factors catalytic domain | Ras-like guanine nucleotide exchange factor |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A2RRV5 | InterPro | 713 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sos1-201
(1)
|
Ensembl | 2,142 nt | ||
| mRNA |
sos1-202
(1)
|
Ensembl | 454 nt | ||
| mRNA |
sos1-204
(1)
|
Ensembl | 3,647 nt | ||
| mRNA |
sos1-205
(1)
|
Ensembl | 810 nt | ||
| mRNA |
sos1-206
(1)
|
Ensembl | 332 nt | ||
| mRNA |
sos1-207
(1)
|
Ensembl | 849 nt | ||
| ncRNA |
sos1-005
(1)
|
Ensembl | 505 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers