Gene
nr0b1
- ID
- ZDB-GENE-070130-1
- Name
- nuclear receptor subfamily 0, group B, member 1
- Symbol
- nr0b1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable transcription corepressor activity. Acts upstream of or within multicellular organismal-level water homeostasis and negative regulation of male gonad development. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; digestive system; fin; interrenal primordium; and reproductive system. Human ortholog(s) of this gene implicated in 46,XY sex reversal 2 and X-linked adrenal hypoplasia congenita. Orthologous to human NR0B1 (nuclear receptor subfamily 0 group B member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017613 (7 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| 46,XY sex reversal 2 | Alliance | 46XY sex reversal 2, dosage-sensitive | 300018 |
| X-linked adrenal hypoplasia congenita | Alliance | Adrenal hypoplasia, congenital | 300200 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Nuclear receptor subfamily 0 group B member 1/2 |
|---|---|---|---|---|---|
|
UniProtKB:A3KNP5
|
264 |
Interactions and Pathways
Plasmids
No data available