Gene
celsr2
- ID
- ZDB-GENE-070122-2
- Name
- cadherin, EGF LAG seven-pass G-type receptor 2
- Symbol
- celsr2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Acts upstream of or within several processes, including cell-cell adhesion; epiboly involved in gastrulation with mouth forming second; and facial nucleus development. Located in plasma membrane. Is expressed in several structures, including central nervous system; eye; neural plate; ovary; and spinal cord neural tube. Orthologous to human CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000203 | GPS motif |
| Conserved_site | IPR020894 | Cadherin conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001791 | Laminin G domain |
| Domain | IPR001879 | GPCR, family 2, extracellular hormone receptor domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR002049 | Laminin-type EGF domain |
| Domain | IPR002126 | Cadherin-like |
| Domain | IPR017981 | GPCR, family 2-like, 7TM |
| Domain | IPR056286 | CELSR1-3-like, ninth cadherin domain |
| Family | IPR000832 | GPCR, family 2, secretin-like |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR015919 | Cadherin-like superfamily |
| Homologous_superfamily | IPR036445 | GPCR family 2, extracellular hormone receptor domain superfamily |
| Homologous_superfamily | IPR046338 | GAIN domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cadherin conserved site | Cadherin-like | Cadherin-like superfamily | CELSR1-3-like, ninth cadherin domain | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like calcium-binding domain | EGF-like domain | GAIN domain superfamily | GPCR, family 2, extracellular hormone receptor domain | GPCR family 2, extracellular hormone receptor domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPS motif | Growth factor receptor cysteine-rich domain superfamily | Laminin G domain | Laminin-type EGF domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0JBX1 | InterPro | 2941 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
celsr2-201
(1)
|
Ensembl | 8,823 nt | ||
| mRNA |
celsr2-202
(1)
|
Ensembl | 3,813 nt | ||
| mRNA |
celsr2-203
(1)
|
Ensembl | 728 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance