header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-070122-2
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.
Gene Name: cadherin, EGF LAG seven-pass G-type receptor 2
Gene Symbol: celsr2    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: celsr2l, fmi2 (1), off-road, ord, si:rp71-11b17.1, si:rp71-11b17.9 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have G protein-coupled receptor activity and calcium ion binding activity. Involved in several processes, including cell-cell adhesion; epiboly involved in gastrulation with mouth forming second; and facial nucleus development. Localizes to the plasma membrane. Is expressed in brain; eye; and ovary. Orthologous to human CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2).
Genome Resources: Alliance (1),  Gene:560426 (1),  Ensembl(GRCz11):ENSDARG00000019726 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
celsr2_unspecified Unspecified Unknown Unknown
rw71 Point Mutation Unknown Unknown
rw135 Point Mutation Unknown Unknown
rw166 Point Mutation Unknown Unknown
rw380 Point Mutation Unknown Unknown
sa15866 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa24041 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa24043 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa43733 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa43735 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-celsr2 N/A 1
    MO2-celsr2 N/A 1
    PHENOTYPE
    Data: 6 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH celsr2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH celsr2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell-cell adhesion (more)
    Cellular Component plasma membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000203 (1)
  • InterPro:IPR000742 (1)
  • InterPro:IPR000832 (1)
  • InterPro:IPR001791 (1)
  • InterPro:IPR001879 (1)
  • InterPro:IPR001881 (1)
  • InterPro:IPR002049 (1)
  • InterPro:IPR002126 (1)
  • InterPro:IPR009030 (1)
  • InterPro:IPR013032 (1)
  • InterPro:IPR013320 (1)
  • InterPro:IPR015919 (1)
  • InterPro:IPR017981 (1)
  • InterPro:IPR020894 (1)
  • InterPro:IPR032471 (1)
  • InterPro:IPR036445 (1)
  • PROSITE:PS00022 (1)
  • PROSITE:PS00232 (1)
  • PROSITE:PS01186 (1)
  • PROSITE:PS01248 (1)
  • PROSITE:PS50025 (1)
  • PROSITE:PS50026 (1)
  • PROSITE:PS50027 (1)
  • PROSITE:PS50221 (1)
  • PROSITE:PS50227 (1)
  • PROSITE:PS50261 (1)
  • Pfam:PF00002 (1)
  • Pfam:PF00008 (1)
  • Pfam:PF00028 (1)
  • Pfam:PF00053 (1)
  • Pfam:PF01825 (1)
  • Pfam:PF02210 (1)
  • Pfam:PF16489 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA celsr2-202 (1)    Ensembl 3813
    Select Tool
    celsr2-203 (1)    Ensembl 728
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM celsr2 No data available
    MARKER RELATIONSHIPS
    celsr2 Contained in: [BAC] RP71-11B17 (1) (order this)
    celsr2 Encodes: [EST] wz12434
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001080577 (1) 8826 bp
    Select Tool
    Genomic GenBank:AL645789 (1) 167635 bp
    Select Tool
    Polypeptide UniProtKB:A0JBX1 (1) 2941 aa
    Select Tool
    Sequence Clusters UniGene:110394 (1)
    Sequence Information (all 16)
    ORTHOLOGY for celsr2 ( Chr: 22 )
    CITATIONS (29)