Gene

obscnb

ID
ZDB-GENE-070119-5
Name
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b
Symbol
obscnb Nomenclature History
Previous Names
  • obscnl
  • obscurin A (1)
  • si:rp71-18a8.2
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to have guanyl-nucleotide exchange factor activity. Involved in myofibril assembly and retina development in camera-type eye. Localizes to M band. Is expressed in central nervous system; heart; retinal neural layer; skeletal muscle; and skeletal muscle cell. Orthologous to human OBSCN (obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With obscnb Human Ortholog
No data available
Associated With obscnb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR000219 Dbl homology (DH) domain
Domain IPR001452 SH3 domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR003961 Fibronectin type III
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR013106 Immunoglobulin V-set domain
Domain IPR035526 Obscurin, SH3 domain
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR035899 Dbl homology (DH) domain superfamily
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Dbl homology (DH) domain Dbl homology (DH) domain superfamily Fibronectin type III Fibronectin type III superfamily Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Immunoglobulin V-set domain IQ motif, EF-hand binding site Obscurin, SH3 domain SH3 domain SH3-like domain superfamily
UniProtKB:X1WFS0 1480
UniProtKB:A0A140LFP6 195
UniProtKB:A0A140LGX4 1010
UniProtKB:A0A140LFP0 1660
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-obscnl polyclonal IgG Rabbit
  • IHC
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations