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ZIRC
ZFIN ID: ZDB-GENE-070117-1989
Gene Name: kinesin family binding protein
Gene Symbol: kifbp    Nomenclature History

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Previous Names: kbp, kif1bp, kifbp, fc59b03, kiaa1279 (1), kif1-binding protein, unm st23, wu:fc59b03, zgc:112085

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Involved in several processes, including central nervous system neuron axonogenesis; enteric nervous system development; and neuron projection maintenance. Predicted to localize to the mitochondrion. Used to study Goldberg-Shprintzen syndrome. Human ortholog(s) of this gene implicated in Goldberg-Shprintzen syndrome. Is expressed in gut and nervous system. Orthologous to human KIFBP (kinesin family binding protein).
Genome Resources: Alliance (1),  Gene:100002194 (1),  Ensembl(GRCz11):ENSDARG00000062053 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12676 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24932 Point Mutation Unknown Premature Stop ENU
    sa31926 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • st23 Point Mutation Intron 5 Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-kifbp N/A 2
    MO2-kifbp N/A 1
    DISEASE ASSOCIATED WITH kifbp HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Goldberg-Shprintzen syndrome Alliance Goldberg-Shprintzen megacolon syndrome 609460
    DISEASE ASSOCIATED WITH kifbp VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Goldberg-Shprintzen syndrome kifbpst23/st23 standard conditions Lyons et al., 2008
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process nervous system development (more)
    Cellular Component mitochondrion (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR011990 (1)
  • InterPro:IPR022083 (1)
  • Pfam:PF12309 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kif1bp-201 (1)    Ensembl 2231
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kifbp No data available
    MARKER RELATIONSHIPS
    kifbp Contained in: [BAC] DKEY-226B20 (order this)
    kifbp Encodes: [EST] fc59b03
    [cDNA] MGC:112085 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001013462 (1) 2237 bp
    Genomic GenBank:BX546482 (1) 206949 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QIJ9 (1) 631 aa
    Sequence Clusters UniGene:39118 (1)
    Sequence Information (all 15)
    ORTHOLOGY for kifbp ( Chr: 13 )
    CITATIONS (30)