Gene

pde8a

ID

ZDB-GENE-070112-622

Name

phosphodiesterase 8A

Symbol

pde8a Nomenclature History

Previous Names

zgc:158458

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to enable 3',5'-cyclic-nucleotide phosphodiesterase activity and metal ion binding activity. Predicted to be involved in cAMP catabolic process. Predicted to act upstream of or within phosphorelay signal transduction system and regulation of DNA-templated transcription. Orthologous to human PDE8A (phosphodiesterase 8A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pde8a Human Ortholog

No data available

Associated With pde8a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023174	3'5'-cyclic nucleotide phosphodiesterase, conserved site
Domain	IPR000014	PAS domain
Domain	IPR002073	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Domain	IPR003607	HD/PDEase domain
Domain	IPR013767	PAS fold
Domain	IPR013938	3'5'-cyclic nucleotide phosphodiesterase PDE8
Family	IPR023088	3'5'-cyclic nucleotide phosphodiesterase
Homologous_superfamily	IPR011006	CheY-like superfamily
Homologous_superfamily	IPR035965	PAS domain superfamily
Homologous_superfamily	IPR036971	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily

Domain Details Per Protein

Protein	Length	3'5'-cyclic nucleotide phosphodiesterase	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily	3'5'-cyclic nucleotide phosphodiesterase, conserved site	3'5'-cyclic nucleotide phosphodiesterase PDE8	CheY-like superfamily	HD/PDEase domain	PAS domain	PAS domain superfamily	PAS fold
UniProtKB:A1L1W3 InterPro	817

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	pde8a-201 (1) Ensembl	Ensembl		1,932 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations