Gene
d2hgdh
- ID
- ZDB-GENE-070112-482
- Name
- D-2-hydroxyglutarate dehydrogenase
- Symbol
- d2hgdh Nomenclature History
- Previous Names
-
- zgc:158661
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have FAD binding activity and oxidoreductase activity. Predicted to be involved in oxidation-reduction process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 1. Orthologous to human D2HGDH (D-2-hydroxyglutarate dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| D-2-hydroxyglutaric aciduria 1 | Alliance | D-2-hydroxyglutaric aciduria | 600721 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004113 | FAD-binding oxidoreductase/transferase, type 4, C-terminal |
| Domain | IPR006094 | FAD linked oxidase, N-terminal |
| Domain | IPR016166 | FAD-binding domain, PCMH-type |
| Family | IPR051264 | FAD-binding Oxidoreductase/Transferase Type 4 |
| Homologous_superfamily | IPR016164 | FAD-linked oxidase-like, C-terminal |
| Homologous_superfamily | IPR016167 | FAD-binding, type PCMH, subdomain 1 |
| Homologous_superfamily | IPR016169 | FAD-binding, type PCMH, subdomain 2 |
| Homologous_superfamily | IPR016171 | Vanillyl-alcohol oxidase, C-terminal subdomain 2 |
| Homologous_superfamily | IPR036318 | FAD-binding, type PCMH-like superfamily |
Domain Details Per Protein
| Protein | Length | FAD-binding domain, PCMH-type | FAD-binding Oxidoreductase/Transferase Type 4 | FAD-binding oxidoreductase/transferase, type 4, C-terminal | FAD-binding, type PCMH-like superfamily | FAD-binding, type PCMH, subdomain 1 | FAD-binding, type PCMH, subdomain 2 | FAD-linked oxidase-like, C-terminal | FAD linked oxidase, N-terminal | Vanillyl-alcohol oxidase, C-terminal subdomain 2 |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A1L258
|
533 | |||||||||
|
UniProtKB:F1R1R3
|
533 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
d2hgdh-201
(1)
|
Ensembl | 1,833 nt |
Interactions and Pathways
No data available
Plasmids
No data available