Gene
mybpc3
- ID
- ZDB-GENE-070112-2362
- Name
- myosin binding protein C3
- Symbol
- mybpc3 Nomenclature History
- Previous Names
-
- hm:zehn0716
- im:6900815
- zgc:152717
- zgc:158442
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable myosin heavy chain binding activity. Acts upstream of or within cardiac chamber morphogenesis; heart contraction; and regulation of heart rate. Predicted to be located in myosin filament. Predicted to be active in M band. Is expressed in anterior macula; heart rudiment; musculature system; pericardial region; and trunk. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1MM; familial hypertrophic cardiomyopathy; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 4. Orthologous to human MYBPC3 (myosin binding protein C3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6900815 (8 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dilated cardiomyopathy 1MM | Alliance | Cardiomyopathy, dilated, 1MM | 615396 |
| dilated cardiomyopathy 1MM | Alliance | Left ventricular noncompaction 10 | 615396 |
| hypertrophic cardiomyopathy 4 | Alliance | Cardiomyopathy, hypertrophic, 4 | 115197 |
1 - 3 of 3
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | MyBP-C, tri-helix bundle domain | Striated Muscle Structural and Regulatory Protein |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QH12 | InterPro | 1294 | ||||||||||
| UniProtKB:A0A8M1N978 | InterPro | 1265 | ||||||||||
| UniProtKB:A0A8M9Q7W1 | InterPro | 1212 | ||||||||||
| UniProtKB:A0A8M9Q1L9 | InterPro | 1302 | ||||||||||
| UniProtKB:A0A8M3B451 | InterPro | 1189 |
1 - 5 of 11 Show all
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mybpc3-201
(1)
|
Ensembl | 3,194 nt | ||
| mRNA |
mybpc3-202
(1)
|
Ensembl | 3,801 nt | ||
| mRNA |
mybpc3-203
(1)
|
Ensembl | 1,064 nt | ||
| mRNA |
mybpc3-204
(1)
|
Ensembl | 938 nt | ||
| mRNA |
mybpc3-205
(1)
|
Ensembl | 760 nt |
1 - 5 of 7 Show all
Interactions and Pathways
No data available
Plasmids
No data available