Gene

mybpc3

ID

ZDB-GENE-070112-2362

Name

myosin binding protein C3

Symbol

mybpc3 Nomenclature History

Previous Names

hm:zehn0716
im:6900815
zgc:152717
zgc:158442

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have myosin heavy chain binding activity. Involved in cardiac chamber morphogenesis and regulation of heart rate. Is expressed in anterior macula; heart rudiment; musculature system; pericardial region; and trunk. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 4. Orthologous to human MYBPC3 (myosin binding protein C3).

Genome Resources

Note

None

Expression

All Expression Data

11 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

IMAGE:6900815 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mybpc3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypertrophic cardiomyopathy 4	Alliance	Cardiomyopathy, hypertrophic, 4	115197
		Cardiomyopathy, dilated, 1MM	615396
		Left ventricular noncompaction 10	615396

Associated With mybpc3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin subtype
Domain	IPR003961	Fibronectin type III
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Domain	IPR040849	MyBP-C, tri-helix bundle domain
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	Fibronectin type III	Fibronectin type III superfamily	Immunoglobulin I-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin subtype	Immunoglobulin subtype 2	MyBP-C, tri-helix bundle domain
UniProtKB:A0A1L1QZU5 InterPro	1287
UniProtKB:A0A1D5NSX5 InterPro	161
UniProtKB:F1QVS1 InterPro	522
UniProtKB:E7EZ79 InterPro	1266
UniProtKB:E9QBD5 InterPro	238
UniProtKB:Q3B7F2 InterPro	371
UniProtKB:E9QCH0 InterPro	294
UniProtKB:F1Q615 InterPro	313
UniProtKB:A1L1W0 InterPro	523

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	mybpc3-203 (1) Ensembl	1064 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	mybpc3-204 (1) Ensembl	938 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	mybpc3-205 (1) Ensembl	760 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	mybpc3-206 (1) Ensembl	877 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	mybpc3-207 (1) Ensembl	4285 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Gene Tree: Ensembl

Citations