Gene

mybpc3

ID

ZDB-GENE-070112-2362

Name

myosin binding protein C3

Symbol

mybpc3 Nomenclature History

Previous Names

hm:zehn0716
im:6900815
zgc:152717
zgc:158442

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have myosin heavy chain binding activity. Involved in cardiac chamber morphogenesis and regulation of heart rate. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 4. Is expressed in anterior macula; heart rudiment; musculature system; pericardial region; and trunk. Orthologous to human MYBPC3 (myosin binding protein C3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 10 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6900815 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mybpc3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dilated cardiomyopathy 1MM	Alliance	Cardiomyopathy, dilated, 1MM	615396
dilated cardiomyopathy 1MM	Alliance	Left ventricular noncompaction 10	615396
hypertrophic cardiomyopathy 4	Alliance	Cardiomyopathy, hypertrophic, 4	115197

Associated With mybpc3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR003961	Fibronectin type III
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Domain	IPR040849	MyBP-C, tri-helix bundle domain
Family	IPR050964	Striated Muscle Structural and Regulatory Protein
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	Fibronectin type III	Fibronectin type III superfamily	Immunoglobulin domain subtype	Immunoglobulin I-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin subtype 2	MyBP-C, tri-helix bundle domain	Striated Muscle Structural and Regulatory Protein
UniProtKB:A0A8M9QH12 InterPro	1294
UniProtKB:A0A8M1N978 InterPro	1265
UniProtKB:A0A8M9Q7W1 InterPro	1212
UniProtKB:A0A8M9Q1L9 InterPro	1302
UniProtKB:A0A8M3B451 InterPro	1189
UniProtKB:Q3B7F2 InterPro	371
UniProtKB:A0A8M9Q7V7 InterPro	1301
UniProtKB:A0A8M3AU87 InterPro	1279
UniProtKB:A0A1L1QZU5 InterPro	1287
UniProtKB:A0A8M9QC07 InterPro	1280

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mybpc3-201 (1) Ensembl	Ensembl	3,194 nt	Select Tool ZFIN BLAST
mRNA	mybpc3-202 (1) Ensembl	Ensembl	3,801 nt	Select Tool ZFIN BLAST
mRNA	mybpc3-203 (1) Ensembl	Ensembl	1,064 nt	Select Tool
mRNA	mybpc3-204 (1) Ensembl	Ensembl	938 nt	Select Tool
mRNA	mybpc3-205 (1) Ensembl	Ensembl	760 nt	Select Tool
mRNA	mybpc3-206 (1) Ensembl	Ensembl	877 nt	Select Tool
mRNA	mybpc3-207 (1) Ensembl	Ensembl	4,285 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations