Gene
pank2
- ID
- ZDB-GENE-070112-1952
- Name
- pantothenate kinase 2
- Symbol
- pank2 Nomenclature History
- Previous Names
-
- zgc:158667 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have pantothenate kinase activity. Involved in nervous system development and vasculature development. Predicted to localize to cytosol and nucleus. Used to study pantothenate kinase-associated neurodegeneration. Human ortholog(s) of this gene implicated in pantothenate kinase-associated neurodegeneration. Is expressed in axial blood vessel; caudal vein plexus; central nervous system; and epidermis. Orthologous to several human genes including PANK2 (pantothenate kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Zizioli et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from Zizioli et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pantothenate kinase-associated neurodegeneration | Alliance | Neurodegeneration with brain iron accumulation 1 | 234200 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| pantothenate kinase-associated neurodegeneration | AB + MO1-pank2 | standard conditions | Zizioli et al., 2016 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | ATPase, nucleotide binding domain | Type II pantothenate kinase |
|---|---|---|---|
|
UniProtKB:A0A8M2B2L8
|
243 | ||
|
UniProtKB:A0A8M2B3B3
|
355 | ||
|
UniProtKB:B8A4W8
|
437 |
Interactions and Pathways
No data available
Plasmids
No data available